Bibliographic Details
| Title: |
The miR-876-5p/SOCS4/STAT3 pathway induced the expression of PD-L1 and suppressed antitumor immune responses. |
| Authors: |
Peng, Hsuan-Yu1,2,3 (AUTHOR), Huang, Yu-Li4 (AUTHOR), Wu, Ping-Hsiu5,6,7,8 (AUTHOR), Li, Li-Jie9,10 (AUTHOR), Peng, Bou-Yue4 (AUTHOR), Wu, Chia-Yu4,11 (AUTHOR), Lin, Yu-Lung12 (AUTHOR), Hsiao, Michael13 (AUTHOR), Chang, Jang-Yang3 (AUTHOR), Mu-Hsin Chang, Peter14,15,16 (AUTHOR), Lee, Hsin-Lun5,6,7,8 (AUTHOR), Chang, Wei-Min1,2 (AUTHOR) weiminchang@tmu.edu.tw |
| Source: |
Cancer Cell International. 3/26/2025, Vol. 25 Issue 1, p1-15. 15p. |
| Abstract: |
Oral squamous cell carcinoma (OSCC) remains a formidable challenge due to its high recurrence rates and poor prognosis. This study focuses on miR-876, a microRNA significantly associated with OSCC recurrence and clinical outcomes. Analysis of miRNA expression profiles from recurrent OSCC patients revealed that miR-876-5p is markedly upregulated in recurrent tumor tissues and the high expression of miR-876-5p correlates with reduced disease-free and overall survival. Functional assays demonstrated that miR-876 enhances OSCC cell growth, migration, and stemness, contributing to chemoresistance. Mechanistically, miR-876-5p directly targets SOCS4, leading to increased STAT3 activation and subsequent upregulation of PD-L1, which facilitates immune evasion. Additionally, exposure to the tobacco-specific carcinogen NNK was found to induce miR-876 expression and STAT3 activation, implicating environmental factors in miR-876 regulation and promote cancer recurrent. These findings identify the miR-876-5p-SOCS4-STAT3 axis as a critical pathway in OSCC progression, highlighting miR-876-5p as a potential biomarker and therapeutic target to improve treatment outcomes in OSCC patients. [ABSTRACT FROM AUTHOR] |
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