Bibliographic Details
| Title: |
Preliminary pharmacokinetic and psychophysical investigations after controlled oral and inhalative consumption of hexahydrocannabinol (HHC). |
| Authors: |
Höfert, Lisa1 (AUTHOR) lisa.hoefert@medizin.uni-leipzig.de, Franz, Benjamin1 (AUTHOR), Groß, Cedric1 (AUTHOR), Kuntze, Delen1 (AUTHOR), Jurásek, Bronislav2 (AUTHOR), Kuchař, Martin2 (AUTHOR), Dreßler, Jan1 (AUTHOR), Becker, Susen1 (AUTHOR), Baumann, Sven1 (AUTHOR) |
| Source: |
Scientific Reports. 3/24/2025, Vol. 15 Issue 1, p1-12. 12p. |
| Subject Terms: |
*FORENSIC toxicology, *CARBOXYLIC acids, *TETRAHYDROCANNABINOL, *PHARMACOKINETICS, *CANNABINOIDS |
| Abstract: |
The semi-synthetic cannabinoid hexahydrocannabinol (HHC) has become a highly discussed topic in forensic toxicology since 2022 due to its legal availability at this time and its psychoactive effects. This study aimed to investigate the pharmacokinetics, effects, and immunological detectability of HHC after oral (25 mg HHC fruit gum) and inhalative (three puffs from HHC vape) consumption with three participants per group. Serum (up to 48 h), urine (up to five days), and saliva (up to 48 h) samples were collected at different relevant time points and analyzed by HPLC-MS/MS for (9R)/(9S)-HHC, 11-hydroxy-HHC, and (9R)/(9S)-HHC carboxylic acid with a fully validated method. Additionally, immunological detectability was investigated with three different commercially available tests. To address the psychoactive effects, the subjective "high" feeling (scale 0–10) was monitored and different psychophysical tests (e.g. modified Romberg test, walk and turn) were conducted. Overall, the pharmacokinetics and effects of HHC were comparable to tetrahydrocannabinol (THC). However, the route of administration as well as inter-individual factors played a crucial role regarding maximum concentrations, pharmacokinetic profiles, and psychoactive effects. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
