Bibliographic Details
| Title: |
Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy. |
| Authors: |
Gu, Chen1 (AUTHOR), Sha, Gengyu1,2 (AUTHOR), Zeng, Binbin1,3 (AUTHOR), Cao, Herong4 (AUTHOR), Cao, Yibo5 (AUTHOR), Tang, Dong6,7,8,9 (AUTHOR) 83392785@qq.com |
| Source: |
Therapeutic Advances in Gastroenterology. 3/18/2025, p1-20. 20p. |
| Subject Terms: |
*FECAL microbiota transplantation, *GUT microbiome, *COLORECTAL cancer, *IMMUNOSUPPRESSION, *DYSBIOSIS |
| Abstract: |
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute to tumor initiation, immune suppression, and inflammation, establishing the microbiota as a key therapeutic target. Fecal microbiota transplantation (FMT) has emerged as a transformative approach to restore microbial balance, enhance immune responses, and reshape the tumor microenvironment. This review explores the mechanisms underlying FMT's therapeutic potential, evaluates its advantages over other microbiota-based interventions, and addresses challenges such as donor selection, safety concerns, and treatment standardization. Looking forward, the integration of FMT into personalized CRC therapies requires robust clinical trials and the identification of predictive biomarkers to optimize its efficacy and safety. Plain language summary: FMT in CRC: microbiota regulation to therapy Colorectal cancer (CRC) progression is tied to gut microbiota dysbiosis. Fecal microbiota transplantation (FMT) restores balance and boosts immunity, offering promise for personalized CRC therapies with further clinical validation. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Complete |
