Bibliographic Details
| Title: |
The impact of different cervical planning target volume designs on efficacy and toxicity in nasopharyngeal carcinoma: a single-center retrospective study. |
| Authors: |
Wang, Lin1 (AUTHOR), Wang, Hui-Min1 (AUTHOR), Tang, Fan1 (AUTHOR), Zhang, Yan-Ting1 (AUTHOR), Shi, Rong-Rong1 (AUTHOR), Wang, Sheng-Hui1 (AUTHOR), Liang, Si-Chao1 (AUTHOR), Gao, Liao-Ming2 (AUTHOR), Chen, Zhi-Ting3 (AUTHOR), Li, Bao-Feng4 (AUTHOR) BaofengLix@163.com, Chen, Bei1 (AUTHOR) cb18789235270@163.com |
| Source: |
BMC Cancer. 3/17/2025, Vol. 25 Issue 1, p1-11. 11p. |
| Subject Terms: |
*NASOPHARYNX cancer, *SURVIVAL rate, *RADIATION doses, *LYMPH nodes, *CONFIDENCE intervals |
| Abstract: |
Background: In nasopharyngeal carcinoma (NPC) patients, two radiation target delineation patterns are used for the cervical lymph node area. Purpose: This study compares the efficacy and toxicity of two radiation target volume delineation patterns for planning target volumes (PTVs) in NPC patients. Methods: This retrospective analysis included 387 non-metastatic NPC patients treated with concurrent chemoradiotherapy from January 2017 to December 2020. Patients were divided into two groups: the 2-PTV group with two dose gradients (50–54 Gy and 66–70 Gy) and the 3-PTV group with an additional 60–63 Gy dose. Results: After a median follow-up of 51.2 months, the 3-year regional relapse-free survival (RRFS) showed no significant differences between the 3-PTV and 2-PTV groups (96.6% [95% confidence interval (CI): 96.5%–96.8%] and 96.3% [95% CI: 96.2%–96.3%]). In the N3 subgroup, the 3-year RRFS was also comparable between the 3-PTV and 2-PTV groups (96.2% [95% CI: 76%–99%] vs. 95% [95% CI: 69%–99%], p = 0.727). Importantly, the 2-PTV group demonstrated significantly lower rates of grade 3/4 dermatitis (5.1% vs. 16.5%; HR 0.88, 95% CI: 0.82–0.94, p = 0.002) and xerostomia (49.6% vs. 67%; HR 0.78, 95% CI: 0.72–0.84, p = 0.002). Conclusions: The 2-PTV regimen achieved equivalent survival outcomes while significantly reducing treatment-related toxicities compared to the 3-PTV approach. These results suggest that the 2-PTV strategy may offer a more favorable therapeutic profile for NPC patients, particularly in minimizing severe dermatitis and xerostomia. [ABSTRACT FROM AUTHOR] |
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