Bibliographic Details
| Title: |
Synergistic Potential of Curcumin–Vancomycin Therapy in Combating Methicillin-Resistant Staphylococcus aureus Infections: Exploring a Novel Approach to Address Antibiotic Resistance and Toxicity. |
| Authors: |
Guleria, Anupam1 (AUTHOR), Fatima, Nida2 (AUTHOR), Shukla, Anuj3 (AUTHOR), Raj, Ritu3 (AUTHOR), Sahu, Chinmoy2 (AUTHOR), Prasad, Narayan1 (AUTHOR) narayan.nephro@gmail.com, Pathak, Ashutosh2 (AUTHOR) ashutoshsgpgi@gmail.com, Kumar, Dinesh3,4 (AUTHOR) dinesh@cbmr.res.in |
| Source: |
Microbial Drug Resistance: Mechanism, Epidemiology, & Disease. Mar2025, Vol. 31 Issue 3, p65-74. 10p. |
| Subject Terms: |
*DRUG resistance in bacteria, *STAPHYLOCOCCUS aureus infections, *BACTERIAL metabolism, *STAPHYLOCOCCUS aureus, *PERITONEAL dialysis, *METHICILLIN-resistant staphylococcus aureus |
| Abstract: |
Methicillin-resistant Staphylococcus aureus (MRSA) infections pose serious treatment challenges, particularly in peritoneal dialysis patients due to their increased susceptibility to infections and antibiotic resistance. Vancomycin, a standard antibiotic treatment for MRSA, is currently being compromised due to the evolution of multidrug-resistant microorganisms. Therefore, there is an urgent need for alternative therapeutic strategies to obstruct the increasing antibiotic resistance and bacterial biofilm formation. The present study explores curcumin, a natural bioactive compound possessing antimicrobial and anti-inflammatory properties, as a potential therapeutic for MRSA. The standard optical density method confirmed the antibacterial activity of curcumin against Staphylococcus aureus (MTCC-3160). Furthermore, we investigated the impact of curcumin on bacterial metabolism. Metabolic analysis of S. aureus culture media over a 20-h period revealed that curcumin exerts bacteriostatic effects by inhibiting specific metabolic pathways, potentially linked to energy and sugar metabolism. Furthermore, the synergistic effect of curcumin combined with vancomycin was assessed against 20 clinical MRSA strains using the broth microdilution method. The results demonstrated that curcumin enhanced the antibacterial activity of vancomycin in 17 strains by reducing its minimum inhibitory concentration (MIC) significantly. The MIC of curcumin and vancomycin has been found to decrease significantly when used in combination, with curcumin's MIC decreased to as low as 0.5 µg/mL and vancomycin's MIC to 0.5 µg/mL for all strains. Synergistic effects were seen in 17 out of 20 strains, having fractional inhibitory concentration index values between 0.04 and 0.56. These findings suggest that curcumin–vancomycin combination therapy could offer an effective treatment strategy for MRSA infections which may combat antibiotic resistance and reduce treatment-related toxicity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Microbial Drug Resistance: Mechanism, Epidemiology, & Disease is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
