| Title: |
Daily fluid intake and brain amyloid deposition: A cohort study. |
| Authors: |
Kim, Jee Wook1,2 (AUTHOR), Byun, Min Soo3,4 (AUTHOR), Yi, Dahyun5 (AUTHOR), Jung, Joon Hyung6 (AUTHOR), Kong, Nayeong7 (AUTHOR), Chang, Yoon Young8 (AUTHOR), Jung, Gijung5 (AUTHOR), Ahn, Hyejin5 (AUTHOR), Lee, Jun-Young4,9 (AUTHOR), Kang, Koung Mi10 (AUTHOR), Sohn, Chul-Ho10 (AUTHOR), Lee, Yun-Sang11 (AUTHOR), Kim, Yu Kyeong12 (AUTHOR), Lee, Dong Young3,4,5 (AUTHOR) selfpsy@snu.ac.kr |
| Source: |
Journal of Alzheimer's Disease. Mar2025, Vol. 104 Issue 1, p138-149. 12p. |
| Subject Terms: |
*APOLIPOPROTEIN E, *APOLIPOPROTEIN E4, *ALZHEIMER'S disease, *DRINKING (Physiology), *OLDER people |
| Abstract: |
Background: Little information is yet available for the association between daily water intake, a modifiable lifestyle factor, and Alzheimer's disease (AD) pathology and cerebrovascular injury in the living human brain. Objective: Our aim was to explore the correlation between daily fluid intake and in vivo AD pathologies (i.e., amyloid-β (Aβ) and tau) and cerebrovascular injury. Methods: 287 cognitively normal (CN) older adults completed extensive clinical assessments, daily fluid intake evaluations, and multimodal brain imaging at both the initial baseline and the subsequent 2-year follow-up. Results: Low daily fluid intake was significantly associated with a higher level or a more rapid increase of Aβ deposition, especially in apolipoprotein E4 negative individuals. Meanwhile, low daily fluid intake was cross-sectionally related with cerebrovascular injury. Conclusions: Our findings suggest that high daily fluid intake is associated with decreased brain amyloid deposition, indicating that sufficient daily fluid intake may be helpful for prevention of AD. [ABSTRACT FROM AUTHOR] |
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| Database: |
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