Bibliographic Details
| Title: |
Mechanical forces in the tumor microenvironment: roles, pathways, and therapeutic approaches. |
| Authors: |
Zhang, Yanli1 (AUTHOR) ylgogogo@163.com, Fu, Qi1 (AUTHOR), Sun, Wenyue1 (AUTHOR), Yue, Qiujuan1 (AUTHOR), He, Ping1 (AUTHOR), Niu, Dong2 (AUTHOR), Zhang, Min1 (AUTHOR) zhangmin-wen@163.com |
| Source: |
Journal of Translational Medicine. 3/12/2025, Vol. 23 Issue 1, p1-20. 20p. |
| Subject Terms: |
*HIPPO signaling pathway, *EXTRACELLULAR fluid, *FLUID pressure, *PHYSIOLOGICAL stress, *TUMOR growth |
| Abstract: |
Tumors often exhibit greater stiffness compared to normal tissues, primarily due to increased deposition within the tumor stroma. Collagen, proteoglycans, laminin, and fibronectin are key components of the extracellular matrix (ECM), interacting to facilitate ECM assembly. Enhanced fiber density and cross-linking within the ECM result in elevated matrix stiffness and interstitial fluid pressure, subjecting tumors to significant physical stress during growth. This mechanical stress is transduced intracellularly via integrins, the Rho signaling pathway, and the Hippo signaling pathway, thereby promoting tumor invasion. Additionally, mechanical pressure fosters glycolysis in tumor cells, boosting energy production to support metastasis. Mechanical cues also regulate macrophage polarization, maintaining an inflammatory microenvironment conducive to tumor survival. In summary, mechanical signals within tumors play a crucial role in tumor growth and invasion. Understanding these signals and their involvement in tumor progression is essential for advancing our knowledge of tumor biology and enhancing therapeutic approaches. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Translational Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
