Bibliographic Details
| Title: |
Physiopathology of High-Altitude Pulmonary Edema. |
| Authors: |
Miserocchi, Giuseppe1 (AUTHOR) giuseppe.miserocchi@unimib.it |
| Source: |
High Altitude Medicine & Biology. Mar2025, Vol. 26 Issue 1, p1-12. 12p. |
| Subject Terms: |
*BLOOD vessel permeability, *PULMONARY edema, *BLOOD gases, *BLOOD flow, *PATHOLOGICAL physiology |
| Abstract: |
Miserocchi, Giuseppe. Physiopathology of high-altitude pulmonary edema. High Alt Med Biol. 26:1–12, 2025.—The air–blood barrier is well designed to accomplish the matching of gas diffusion with blood flow. This function is achieved by maintaining its thickness at ∼0.5 µm, a feature implying to keep extravascular lung water to the minimum. Exposure to hypobaric hypoxia, especially when associated with exercise, is a condition potentially leading to the development of the so-called high-altitude pulmonary edema (HAPE). This article presents a view of the physiopathology of HAPE by merging available data in humans exposed to high altitude with data from animal experimental approaches. A model is also presented to characterize HAPE nonsusceptible versus susceptible individuals based on the efficiency of alveolar-capillary oxygen uptake and estimated morphology of the air–blood barrier. [ABSTRACT FROM AUTHOR] |
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| Database: |
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