Bibliographic Details
| Title: |
Epidemiologic and Genomic Surveillance of Vibrio cholerae and Effectiveness of Single-Dose Oral Cholera Vaccine, Democratic Republic of the Congo. |
| Authors: |
George, Christine Marie1 cmgeorge@jhu.edu, Namunesha, Alves2, Endres, Kelly1, Felicien, Willy2, Sanvura, Presence2, Bisimwa, Jean-Claude2, Perin, Jamie1, Bengehya, Justin3, Kulondwa, Jean Claude3, Maheshe, Ghislain2, Cikomola, Cirhuza2, Bisimwa, Lucien2, Mwishingo, Alain2, Sack, David A.1, Domman, Daryl4 |
| Source: |
Emerging Infectious Diseases. Feb2025, Vol. 31 Issue 2, p288-297. 10p. |
| Subject Terms: |
*CHOLERA vaccines, *ORAL vaccines, *VIBRIO cholerae, *WHOLE genome sequencing, *VACCINE effectiveness |
| Geographic Terms: |
CONGO |
| Abstract: |
We conducted 4 years of epidemiologic and genomic surveillance of single-dose effectiveness of a killed whole-cell oral cholera vaccine (kOCV) and Vibrio cholerae transmission in the Democratic Republic of the Congo. We enrolled 1,154 patients with diarrhea; 342 of those had culture-confirmed cholera. We performed whole-genome sequencing on clinical and water V. cholerae isolates from 200 patient households, which showed annual bimodal peaks of V. cholerae clade AFR10e infections. A large clonal cholera outbreak occurred 14 months after a kOCV campaign of >1 million doses, likely because of low (9%) vaccine coverage in informal settlements. Clinical and water isolates collected in the same household were closely related, suggesting person-to-person and water-to-person transmission. Single-dose kOCV vaccine effectiveness 24 months after vaccination was 59.8% (95% CI 19.7%--79.9%), suggesting modest single-dose kOCV protection. kOCV campaigns combined with water, sanitation, and hygiene programs should be used to reduce cholera in disease-endemic settings worldwide. [ABSTRACT FROM AUTHOR] |
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| Database: |
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