| Title: |
Resistance to Thyroid Hormone in a Boy with a Severe, Complex, Congenital Heart Defect (CHD) Requiring Multiple Cardiac Surgeries—Whether and How to Prepare Child for the Surgery. |
| Authors: |
Fedorczak, Anna1 (AUTHOR) anna.fedorczak@outlook.com, Kruk, Beata2 (AUTHOR) b.slap@interia.pl, Mazurek-Kula, Anna2 (AUTHOR) qla@op.pl, Kępczyński, Łukasz3 (AUTHOR) lukasz.kepczynski@iczmp.edu.pl, Stawerska, Renata1,4 (AUTHOR) renata.stawerska@icloud.com |
| Source: |
Journal of Clinical Medicine. Feb2025, Vol. 14 Issue 4, p1209. 7p. |
| Subject Terms: |
*THYROID hormone receptors, *CONGENITAL heart disease, *HORMONE receptors, *THYROID hormones, *CARDIAC surgery |
| Abstract: |
Background: Resistance to thyroid hormones (RTH) is a rare, genetically determined disease characterised by reduced tissue sensitivity to thyroid hormones (THs). It is caused by mutations in genes encoding the receptors for thyroid hormones, α (THRα) or β (THRβ), the distribution of which varies between tissues. Therefore, patients present with elevated TH levels with unsuppressed TSH levels, and symptoms of both hypothyroidism and hyperthyroidism may be present. Methods: Hence, we report the case of a boy with a complex, cyanotic, congenital heart defect who was also diagnosed with TH resistance syndrome. Results: Because of the clinical features of hyperthyroidism in preparation for cardiac surgery, thiamazole was administered, resulting in the normalisation of TH effects on the α-receptor for HTs. Due to the effectiveness of the proposed treatment, it was further introduced before the further stages of cardiac surgeries. Conclusions: The management of RTH is a constant challenge for clinicians and must be individualised. [ABSTRACT FROM AUTHOR] |
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| Database: |
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