Notch and Hedgehog Signaling Unveiled: Crosstalk, Roles, and Breakthroughs in Cancer Stem Cell Research.
| Title: | Notch and Hedgehog Signaling Unveiled: Crosstalk, Roles, and Breakthroughs in Cancer Stem Cell Research. |
|---|---|
| Authors: | Iluta, Sabina1 (AUTHOR) iluta.sabina@yahoo.com, Nistor, Madalina2 (AUTHOR) madalina.nistor7@gmail.com, Buruiana, Sanda3 (AUTHOR) sanda.buruiana@usmf.md, Dima, Delia4 (AUTHOR) deldima@yahoo.com |
| Source: | Life (2075-1729). Feb2025, Vol. 15 Issue 2, p228. 22p. |
| Subject Terms: | *CANCER stem cells, *NOTCH signaling pathway, *STEM cell research, *HEDGEHOG signaling proteins, *STEM cell treatment, *NOTCH genes, *WNT signal transduction |
| Abstract: | The development of therapies that target cancer stem cells (CSCs) and bulk tumors is both crucial and urgent. Several signaling pathways, like Notch and Hedgehog (Hh), have been strongly associated with CSC stemness maintenance and metastasis. However, the extensive crosstalk present between these two signaling networks complicates the development of long-term therapies that also minimize adverse effects on healthy tissues and are not overcome by therapy resistance from CSCs. The present work aims to overview the roles of Notch and Hh in cancer outburst and the intersection of the two pathways with one another, as well as with other networks, such as Wnt/β-catenin, TGF, and JAK/STAT3, and to explore the shaping of the tumor microenvironment (TME) with specific influence on CSC development and maintenance. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Notch and Hedgehog Signaling Unveiled: Crosstalk, Roles, and Breakthroughs in Cancer Stem Cell Research. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Iluta%2C+Sabina%22">Iluta, Sabina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> iluta.sabina@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Nistor%2C+Madalina%22">Nistor, Madalina</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> madalina.nistor7@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Buruiana%2C+Sanda%22">Buruiana, Sanda</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> sanda.buruiana@usmf.md</i><br /><searchLink fieldCode="AR" term="%22Dima%2C+Delia%22">Dima, Delia</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> deldima@yahoo.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Life+%282075-1729%29%22">Life (2075-1729)</searchLink>. Feb2025, Vol. 15 Issue 2, p228. 22p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22CANCER+stem+cells%22">CANCER stem cells</searchLink><br />*<searchLink fieldCode="DE" term="%22NOTCH+signaling+pathway%22">NOTCH signaling pathway</searchLink><br />*<searchLink fieldCode="DE" term="%22STEM+cell+research%22">STEM cell research</searchLink><br />*<searchLink fieldCode="DE" term="%22HEDGEHOG+signaling+proteins%22">HEDGEHOG signaling proteins</searchLink><br />*<searchLink fieldCode="DE" term="%22STEM+cell+treatment%22">STEM cell treatment</searchLink><br />*<searchLink fieldCode="DE" term="%22NOTCH+genes%22">NOTCH genes</searchLink><br />*<searchLink fieldCode="DE" term="%22WNT+signal+transduction%22">WNT signal transduction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The development of therapies that target cancer stem cells (CSCs) and bulk tumors is both crucial and urgent. Several signaling pathways, like Notch and Hedgehog (Hh), have been strongly associated with CSC stemness maintenance and metastasis. However, the extensive crosstalk present between these two signaling networks complicates the development of long-term therapies that also minimize adverse effects on healthy tissues and are not overcome by therapy resistance from CSCs. The present work aims to overview the roles of Notch and Hh in cancer outburst and the intersection of the two pathways with one another, as well as with other networks, such as Wnt/β-catenin, TGF, and JAK/STAT3, and to explore the shaping of the tumor microenvironment (TME) with specific influence on CSC development and maintenance. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/life15020228 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 22 StartPage: 228 Subjects: – SubjectFull: CANCER stem cells Type: general – SubjectFull: NOTCH signaling pathway Type: general – SubjectFull: STEM cell research Type: general – SubjectFull: HEDGEHOG signaling proteins Type: general – SubjectFull: STEM cell treatment Type: general – SubjectFull: NOTCH genes Type: general – SubjectFull: WNT signal transduction Type: general Titles: – TitleFull: Notch and Hedgehog Signaling Unveiled: Crosstalk, Roles, and Breakthroughs in Cancer Stem Cell Research. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Iluta, Sabina – PersonEntity: Name: NameFull: Nistor, Madalina – PersonEntity: Name: NameFull: Buruiana, Sanda – PersonEntity: Name: NameFull: Dima, Delia IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20751729 Numbering: – Type: volume Value: 15 – Type: issue Value: 2 Titles: – TitleFull: Life (2075-1729) Type: main |
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