Bibliographic Details
| Title: |
Effects of Repetitive Transcranial Magnetic Stimulation Applied over the Primary Motor Cortex on the Offset Analgesia Phenomenon. |
| Authors: |
Antoniazzi, Elisa1 (AUTHOR) elisa.antoniazzi@mondino.it, Cavigioli, Camilla1 (AUTHOR) camilla.cavigioli01@universitadipavia.it, Tang, Vanessa1 (AUTHOR) vanessa.tang01@universitadipavia.it, Zoccola, Clara1 (AUTHOR) clara.zoccola01@universitadipavia.it, Todisco, Massimiliano1 (AUTHOR) massimiliano.todisco@mondino.it, Tassorelli, Cristina2,3 (AUTHOR), Cosentino, Giuseppe1,2 (AUTHOR) giuseppe.cosentino@unipv.it |
| Source: |
Life (2075-1729). Feb2025, Vol. 15 Issue 2, p182. 18p. |
| Subject Terms: |
*ANALGESIA, *PAIN management, *CHRONIC pain, *PAIN threshold, *PAIN measurement, *MOTOR cortex, *TRANSCRANIAL magnetic stimulation, *FOREARM |
| Abstract: |
In this study, we investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left upper limb primary motor cortex (M1) on the offset analgesia (OA) phenomenon, a measure of endogenous pain modulation. In particular, we aim to determine whether rTMS influences OA differently in the forearm region, corresponding to the stimulated cortical area, compared to the trigeminal region. Twenty-two healthy volunteers underwent three experimental sessions: a baseline session without stimulation, an active rTMS session, and a sham rTMS session. Quantitative sensory testing (QST) paradigms, including warm and cold detection thresholds, heat pain threshold corresponding to a visual analogue scale (VAS) score of approximately 50–60 out of 100 (Pain50–60), and constant and offset trials, were assessed in both the forearm and trigeminal regions. The results revealed that active rTMS significantly enhanced the OA phenomenon in the forearm during the late phase, while no significant effects were observed in the trigeminal region. These findings suggest that rTMS may modulate central pain mechanisms in a body region-specific manner, potentially linked to the somatotopic organization of M1. This study points to possible mechanisms of action of rTMS for pain relief, highlighting the importance of region-specific effects in chronic pain treatment. Further research is needed to investigate the underlying mechanisms and clinical applicability of rTMS in patients with chronic pain conditions, especially when OA is compromised. [ABSTRACT FROM AUTHOR] |
|
Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
