| Title: |
The Interplay Between Immunity, Inflammation and Endothelial Dysfunction. |
| Authors: |
Chee, Ying Jie1,2 (AUTHOR) cheeyingjie_chee@ttsh.com.sg, Dalan, Rinkoo1,2 (AUTHOR), Cheung, Christine2,3 (AUTHOR) |
| Source: |
International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1708. 34p. |
| Subject Terms: |
*METABOLIC disorders, *ENDOTHELIUM diseases, *ENDOTHELIUM, *OXIDATIVE stress, *DRUG target |
| Abstract: |
The endothelium is pivotal in multiple physiological processes, such as maintaining vascular homeostasis, metabolism, platelet function, and oxidative stress. Emerging evidence in the past decade highlighted the immunomodulatory function of endothelium, serving as a link between innate, adaptive immunity and inflammation. This review examines the regulation of the immune–inflammatory axis by the endothelium, discusses physiological immune functions, and explores pathophysiological processes leading to endothelial dysfunction in various metabolic disturbances, including hyperglycemia, obesity, hypertension, and dyslipidaemia. The final section focuses on the novel, repurposed, and emerging therapeutic targets that address the immune–inflammatory axis in endothelial dysfunction. [ABSTRACT FROM AUTHOR] |
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