Bibliographic Details
| Title: |
Thioureas Derived from (S)-1-(2-pyridyl)ethylamine Enantiomer: Synthesis and Selected Applications as an Organocatalyst. |
| Authors: |
Chrzanowski, Jacek1 (AUTHOR), Sancineto, Luca2 (AUTHOR), Deska, Malgorzata3 (AUTHOR), Rachwalski, Michal4 (AUTHOR), Drabowicz, Jozef1,3 (AUTHOR) |
| Source: |
Symmetry (20738994). Feb2025, Vol. 17 Issue 2, p216. 10p. |
| Subject Terms: |
*ASYMMETRIC synthesis, *ALDOL condensation, *OPTICAL resolution, *THIOUREA, *ISOTHIOCYANATES |
| Abstract: |
In order to expand the group of chiral thiourea structures, several optically active thioureas derived from the (S)-1-(2-pyridyl)ethylamine enantiomer were prepared via its reaction with achiral or optically active isothiocyanates. To show their synthetic potential as chiral auxiliaries the isolated thioureas were tested as an optically active organocatalyst in the asymmetric version of the selected aldol condensation and addition of diethylzinc to benzaldehyde. The observation of asymmetric induction in these model reactions encourages further research on the use of this group of thioureas in asymmetric versions of multicomponent reactions and cycloadditions. The mechanistic aspects of the reactions under study are also briefly discussed. [ABSTRACT FROM AUTHOR] |
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