| Title: |
Exercise-Driven Comprehensive Recovery: Pulmonary Rehabilitation's Impact on Lung Function, Mechanics, and Immune Response in Post-COVID-19 Patients. |
| Authors: |
Brandao-Rangel, Maysa Alves Rodrigues1 (AUTHOR), Brill, Boris2 (AUTHOR), Furtado, Guilherme Eustáquio3,4 (AUTHOR), Freitas-Rolim, Catharine Cássia Lanna4,5 (AUTHOR), Silva-Reis, Anamei5 (AUTHOR), Souza-Palmeira, Victor Hugo1,6 (AUTHOR), Moraes-Ferreira, Renilson1,7 (AUTHOR), Lopes-Silva, Vanessa1 (AUTHOR), Albertini, Regiane1,2 (AUTHOR), Fernandes, Wendel Simões1,3 (AUTHOR), Ferreira, Sérgio César1,4 (AUTHOR), Ferreira, Ricardo César Alves1,5 (AUTHOR), Mateus-Silva, Jose Roberto6 (AUTHOR), Oliveira, Carlos Rocha6,7 (AUTHOR), Frison, Claudio Ricardo1 (AUTHOR), Vieira, Rodolfo P.1,5,7 (AUTHOR) rodrelena@yahoo.com.br |
| Source: |
Infectious Disease Reports. Feb2025, Vol. 17 Issue 1, p1. 16p. |
| Subject Terms: |
*POST-acute COVID-19 syndrome, *AEROBIC exercises, *RESPIRATORY organs, *AIRWAY resistance (Respiration), *MUSCLE strength |
| Abstract: |
Introduction: We sought to evaluate the effects of a 12-week pulmonary rehabilitation (PR) program on lung function, mechanics, as well as pulmonary and systemic inflammation in a cohort of 33 individuals with moderate to severe post-COVID-19. Material and Methods: The pulmonary rehabilitation (PR) program employed a combination of aerobic and resistance exercises. Thirty minutes of treadmill training at 75% of the maximum heart rate, combined with 30 min resistance training consisting of 75% of one maximum repetition, three times a week throughout 12 weeks. Results: PR improved the lung function, FVC (p < 0.02), FEV1 (p < 0.02), FEV1/FVC (p < 0.01), MEF25% (p < 0.006), MEF50% (p < 0.03), and MEF75% (p < 0.02). PR also positively influenced lung mechanics, reducing respiratory impedance (Z5Hz, p < 0.03), respiratory reactance (X5Hz, p < 0.01), resistance of the entire respiratory system (R5Hz, p < 0.03), central airway resistance (RCentral, p < 0.03), and peripheral airway resistance (RPeripheral, p < 0.02). Moreover, muscle strength gains were evident, with significant improvements observed in hand grip strength for both the right (p < 0.02) and left (p < 0.01) hands, as well as maximal inspiratory (p < 0.02) and expiratory (p < 0.03) pressures. Additionally, PR exhibited anti-inflammatory effects by reducing the pro-inflammatory cytokines IL-1β (p < 0.0001) and IL-6 (p < 0.0001) and increasing the anti-inflammatory IL-1RA (p < 0.0004) and IL-10 (p < 0.003) and anti-viral IFN-γ (p < 0.0002) and IFN-β (p < 0.008) cytokines in breath condensate and serum samples. Conclusions: Collectively, these findings highlight the effectiveness of PR in ameliorating COVID-19 sequel across respiratory system, skeletal muscle, and immune responses. This highlights its promising potential as a therapeutic intervention for individuals recovering from COVID-19. [ABSTRACT FROM AUTHOR] |
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