Bibliographic Details
| Title: |
Predictive roles of Asprosin and Gremlin-1 expression in Egyptian pediatric patients with type 1 diabetes. |
| Authors: |
Abas, Al-shimaa M.1 (AUTHOR) dr_shmma@yahoo.com, Esawy, Marwa M.2 (AUTHOR), Kamel, Fatma3 (AUTHOR), Ali, Mohamed1 (AUTHOR) |
| Source: |
Scientific Reports. 2/20/2025, Vol. 15 Issue 1, p1-10. 10p. |
| Subject Terms: |
*TYPE 1 diabetes, *CHILD patients, *MEDICAL sciences, *DIABETES, *ADIPOKINES |
| Abstract: |
Diabetes mellitus type 1 (insulin-dependent) (T1DM) is characterized by the selective destruction of the insulin-producing pancreatic beta. Asprosin and Gremlin-1 may have roles in T1DM, however these roles are not fully established. The expression of Asprosin and Gremlin-1 genes and their protein levels, was considerably higher in T1DM patients' blood compared to the control group (P < 0.001). The area under the curve of 50 age- and sex-matched control persons was compared to that of serum T1DM patients. Gremlin-1 and Asprosin serum quantities were measured by ELISA, and real-time PCR was used to evaluate the expression of their genes in peripheral blood. Serum Asprosin concentration, Asprosin expression, serum Gremlin-1 concentration, and Gremlin-1 expression were 0.87, 0.997, 0.912, and 0.949, respectively. The Asprosin expression was the best marker for T1DM diagnosis with 96% sensitivity, 92% specificity, and 94% accuracy. Asprosin expression can significantly increase the risk of T1DM by 276 folds, followed by Gremlin-1 expression by 84.33 folds. The best diagnostic for T1DM diagnosis was Asprosin expression, which had 96% sensitivity, 92% specificity, and 94% accuracy. The risk of type 1 diabetes can be raised by 276 times when asprosin expression is present, and by 84.33 times when Gremlin-1 expression is present. [ABSTRACT FROM AUTHOR] |
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