Bibliographic Details
| Title: |
The integrated stress response in neurodegenerative diseases. |
| Authors: |
Bravo-Jimenez, Maria Astrid1 (AUTHOR) astrid.bravoj@gmail.com, Sharma, Shivangi1 (AUTHOR) shivangi.sharma@umanitoba.ca, Karimi-Abdolrezaee, Soheila1 (AUTHOR) Soheila.Karimi@umanitoba.ca |
| Source: |
Molecular Neurodegeneration. 2/19/2025, Vol. 20 Issue 1, p1-20. 20p. |
| Subject Terms: |
*NEURODEGENERATION, *MEDICAL sciences, *CENTRAL nervous system, *CYTOLOGY, *LIFE sciences, *PROTEIN folding |
| Abstract: |
The integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to diverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis in response to internal or external stresses. In recent years, the ISR has emerged as an important regulator of the central nervous system (CNS) development, homeostasis and pathology. Dysregulation of ISR signaling has been linked to several neurodegenerative diseases. Intriguingly, while acute ISR provide neuroprotection through the activation of cell survival mechanisms, prolonged ISR can promote neurodegeneration through protein misfolding, oxidative stress, and mitochondrial dysfunction. Understanding the molecular mechanisms and dynamics of the ISR in neurodegenerative diseases aids in the development of effective therapies. Here, we will provide a timely review on the cellular and molecular mechanisms of the ISR in neurodegenerative diseases. We will highlight the current knowledge on the dual role that ISR plays as a protective or disease worsening pathway and will discuss recent advances on the therapeutic approaches that have been developed to target ISR activity in neurodegenerative diseases. [ABSTRACT FROM AUTHOR] |
|
Copyright of Molecular Neurodegeneration is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
