Bibliographic Details
| Title: |
Association between triglyceride glucose-body mass index and gestational diabetes mellitus: a prospective cohort study. |
| Authors: |
Liang, Xiaomin1 (AUTHOR) 171283296@qq.com, Lai, Kai1 (AUTHOR) lk_fe@163.com, Li, Xiaohong1 (AUTHOR) 26388956@qq.com, Ren, Di1 (AUTHOR) 59192570@qq.com, Gui, Shuiqing1 (AUTHOR) guishuiqing@163.com, Li, Ying1 (AUTHOR) liying20020813@163.com, Xing, Zemao1 (AUTHOR) zemaox@126.com |
| Source: |
BMC Pregnancy & Childbirth. 2/17/2025, Vol. 25 Issue 1, p1-9. 9p. |
| Subject Terms: |
*GESTATIONAL diabetes, *PREGNANT women, *RECEIVER operating characteristic curves, *LOGISTIC regression analysis, *ODDS ratio |
| Abstract: |
Background: Limited research has examined the potential association between triglyceride glucose-body mass index (TyG-BMI) and gestational diabetes mellitus (GDM). The objective of this investigation was to analyze this linkage and evaluate TyG-BMI's capability to predict GDM. Methods: This research employed secondary data derived from a prospective cohort in South Korea, which included 588 pregnant women with singleton gestations, collected between November 2014 and July 2016. To investigate the connection between TyG-BMI and GDM, logistic regression and sensitivity analyses were performed. Furthermore, an analysis of receiver operating characteristics (ROC) was conducted to assess the prognostic accuracy of TyG-BMI in relation to GDM. Results: The cohort exhibited a mean age of 32.07 ± 3.80 years, with 36 individuals (6.12%) manifesting GDM during the interval of 24 to 28 weeks of gestation. Following the adjustment for possible confounding variables, an increased TyG-BMI was associated with an elevated risk of GDM, as indicated by an odds ratio (OR) of 1.02 (95% CI: 1.01–1.04). Additionally, the area under the curve (AUC) for TyG-BMI's predictive performance was recorded at 0.7979 (0.7143–0.8814), with an optimal threshold established at 211.03, which resulted in a specificity of 86.23% and a sensitivity of 66.67%. Conclusions: In this South Korean cohort, increased TyG-BMI during early pregnancy (10–14 weeks) was significantly associated with the onset of GDM (during pregnancy 24–28 weeks). TyG-BMI could be integrated into clinical practice as a complementary preliminary screening tool for detecting women who are at increased risk of GDM. [ABSTRACT FROM AUTHOR] |
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