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In Silico Characterization of Sirtuins in Acetic Acid Bacteria Reveals a Novel Phylogenetically Distinctive Group.

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Title: In Silico Characterization of Sirtuins in Acetic Acid Bacteria Reveals a Novel Phylogenetically Distinctive Group.
Authors: Jugović, Igor1 (AUTHOR) igorjugovic444@gmail.com, Trček, Janja1,2 (AUTHOR) janja.trcek@bf.uni-lj.si
Source: Molecules. Feb2025, Vol. 30 Issue 3, p635. 27p.
Subject Terms: *ACETOBACTER, *UNICELLULAR organisms, *BACTERIAL genomes, *SIRTUINS, *ACETIC acid
Abstract: Acetic acid bacteria are single-celled organisms well-known for their ability to convert ethanol into acetic acid. Still, recent research suggests they may harbor another attractive characteristic—the production of proteins with remarkable similarities to sirtuins. Sirtuins have been linked to lifespan extension in various organisms, raising intriguing questions about the potential connection between acetic acid bacteria and the biology of aging. This article delves into the characterization of sirtuin homologs in acetic acid bacteria. Up to three types of sirtuin homologs have been identified in 21% of acetic acid bacteria genomes deposited in NCBI. All three types were present only in the genera Acetobacter and Novacetimonas, which are known to survive in the harshest environmental conditions (high concentrations of acetic acid and ethanol). Interestingly, two types of these sirtuin homologs (SirAAB-L and SirAAB-S) constitute a separate group (SirAAB), distinctive from all other presently known sirtuins. The results obtained in silico thus encourage further studies into the function of these types of sirtuins and their interplay with metabolic pathways in these industrially important bacteria. [ABSTRACT FROM AUTHOR]
Copyright of Molecules is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: In Silico Characterization of Sirtuins in Acetic Acid Bacteria Reveals a Novel Phylogenetically Distinctive Group.
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  Data: <searchLink fieldCode="AR" term="%22Jugović%2C+Igor%22">Jugović, Igor</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> igorjugovic444@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Trček%2C+Janja%22">Trček, Janja</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> janja.trcek@bf.uni-lj.si</i>
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  Data: <searchLink fieldCode="JN" term="%22Molecules%22">Molecules</searchLink>. Feb2025, Vol. 30 Issue 3, p635. 27p.
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  Data: *<searchLink fieldCode="DE" term="%22ACETOBACTER%22">ACETOBACTER</searchLink><br />*<searchLink fieldCode="DE" term="%22UNICELLULAR+organisms%22">UNICELLULAR organisms</searchLink><br />*<searchLink fieldCode="DE" term="%22BACTERIAL+genomes%22">BACTERIAL genomes</searchLink><br />*<searchLink fieldCode="DE" term="%22SIRTUINS%22">SIRTUINS</searchLink><br />*<searchLink fieldCode="DE" term="%22ACETIC+acid%22">ACETIC acid</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Acetic acid bacteria are single-celled organisms well-known for their ability to convert ethanol into acetic acid. Still, recent research suggests they may harbor another attractive characteristic—the production of proteins with remarkable similarities to sirtuins. Sirtuins have been linked to lifespan extension in various organisms, raising intriguing questions about the potential connection between acetic acid bacteria and the biology of aging. This article delves into the characterization of sirtuin homologs in acetic acid bacteria. Up to three types of sirtuin homologs have been identified in 21% of acetic acid bacteria genomes deposited in NCBI. All three types were present only in the genera Acetobacter and Novacetimonas, which are known to survive in the harshest environmental conditions (high concentrations of acetic acid and ethanol). Interestingly, two types of these sirtuin homologs (SirAAB-L and SirAAB-S) constitute a separate group (SirAAB), distinctive from all other presently known sirtuins. The results obtained in silico thus encourage further studies into the function of these types of sirtuins and their interplay with metabolic pathways in these industrially important bacteria. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecules is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/molecules30030635
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      – Code: eng
        Text: English
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        PageCount: 27
        StartPage: 635
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      – SubjectFull: ACETOBACTER
        Type: general
      – SubjectFull: UNICELLULAR organisms
        Type: general
      – SubjectFull: BACTERIAL genomes
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      – SubjectFull: SIRTUINS
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              Text: Feb2025
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              Y: 2025
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