Bibliographic Details
| Title: |
Assessment of Protein Immunoexpression Associated with Tumor Proliferation and Invasion in Histological Subtypes of Unicystic and Conventional Ameloblastoma. |
| Authors: |
da Silveira, Gabriela Cristina Avertano Rocha1 (AUTHOR) gabriela.avertano.rocha@gmail.com, Costa, Rebeca Vieira1 (AUTHOR) rebecavcosta@outlook.com, Lemos, Flavia Letícia Magalhães1 (AUTHOR) leticiamalemos@gmail.com, de Moraes, Antonia Taiane Lopes2 (AUTHOR) taiane_moraes12@hotmail.com, Kataoka, Maria Sueli da Silva3 (AUTHOR) sukataoka@yahoo.com.br, Freitas, Vanessa Morais4 (AUTHOR) vfreitas@usp.br, de Menezes, Silvio Augusto Fernandes5 (AUTHOR) menezes@cesupa.br, Vasconcelos, Ana Carolina Uchoa6 (AUTHOR) carolinauv@gmail.com, Etges, Adriana6 (AUTHOR) aetges@gmail.com, Santos, Fabricio Passador7 (AUTHOR) fabricio.passadorsantos@slmandic.edu.br, de Araújo, Vera Cavalcanti7 (AUTHOR) vcaraujo@usp.br, Alves Júnior, Sérgio de Melo1 (AUTHOR) sergioalves@ufpa.br, Jaeger, Ruy Gastaldoni4 (AUTHOR) rgjaeger@usp.br, Pinheiro, João de Jesus Viana1 (AUTHOR) radface@hotmail.com |
| Source: |
International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1267. 13p. |
| Subject Terms: |
*ODONTOGENIC tumors, *CANCER invasiveness, *AMELOBLASTOMA, *MURAL art, *IMMUNOHISTOCHEMISTRY |
| Abstract: |
The aim of this study was to verify whether the expression of proteins related to the formation of invadopodia, MT1-MMP, cortactin, Tks-4 and Tks-5 is associated with the degree of tumor invasiveness of different types of unicystic ameloblastomas. An immunohistochemical study was performed on 29 unicystic ameloblastoma (UA) samples, 9 conventional ameloblastoma (CAM) samples and 9 dental follicle (DF) samples. The potential for tumor invasiveness was assessed based on the immunoexpression of the following invadopodia-forming proteins: MT1-MMP, cortactin, Tks-4 and Tks5. Mural unicystic ameloblastoma (MUA) showed higher MT1-MMP, cortactin, Tks-4, and Tks-5 immunoexpression than luminal and intra-luminal types. Conventional ameloblastoma exhibited lower MT1-MMP, cortactin, and Tks-5 expression compared to MUA. MUA's cystic capsule neoplastic cells had significantly higher MT1-MMP, cortactin, Tks-4, and Tks-5 expression than lumen cells. Dental follicles showed minimal expression. Neoplastic cells in the cystic capsule of mural unicystic ameloblastomas showed higher invadopodia-related protein expression than lumen and luminal/intraluminal cells, suggesting that proximity to the bone region influences the aggressive behavior of mural unicystic ameloblastomas more compared to other subtypes. [ABSTRACT FROM AUTHOR] |
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