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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis.

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Title: Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis.
Authors: Yue, Ningning1 (AUTHOR), Zhao, Hailan1,2 (AUTHOR), Hu, Peng3 (AUTHOR), Zhang, Yuan4 (AUTHOR), Tian, Chengmei5 (AUTHOR), Kong, Chen1 (AUTHOR), Mai, Zhiliang1 (AUTHOR), Huang, Longbin1 (AUTHOR), Luo, Qianjun6 (AUTHOR), Wei, Daoru7 (AUTHOR), Shi, Ruiyue1 (AUTHOR), Tang, Shaohui2 (AUTHOR), Nie, Yuqiang8 (AUTHOR), Liang, Yujie9 (AUTHOR) liangyjie@126.com, Yao, Jun1,10 (AUTHOR) yj_1108@126.com, Wang, Lisheng1,10 (AUTHOR) wanglsszrmyy@163.com, Li, Defeng1,10 (AUTHOR) ldf830712@163.com
Source: Journal of Nanobiotechnology. 1/31/2025, Vol. 23 Issue 1, p1-23. 23p.
Subject Terms: *ULCERATIVE colitis, *INTESTINAL barrier function, *TIGHT junctions, *GENE expression, *GUT microbiome, *PROBIOTICS
Abstract: Probiotics have been proposed as a potential strategy for managing ulcerative colitis (UC). However, the underlying mechanisms mediating microbiota-host crosstalk remain largely elusive. Here, we report that Limosilactobacillus reuteri (L. reuteri), as a probiotic, secretes cytoplasmic membrane vesicles (CMVs) that communicate with host cells, alter host physiology, and alleviate dextran sulfate sodium (DSS)-induced colitis. First, L. reuteri-CMVs selectively promoted the proliferation of the beneficial bacterium Akkermansia muciniphila (AKK) by upregulating the expression of glycosidases (beta-N-acetylhexosaminidase and alpha-N-acetylglucosaminidase) involved in glycan degradation and metabolic pathways and restored the disrupted gut microbiota balance. Second, L. reuteri-CMVs were taken up by intestinal epithelial cells (IECs), elevated the expression of ZO-1, E-cadherin (Cdh1), and Occludin (Ocln), decreased intestinal permeability, and exerted protective effects on epithelial tight junction functionality. RNA sequencing analysis demonstrated that L. reuteri-CMVs repaired intestinal barrier by activating the HIF-1 signaling pathway and upregulating HMOX1 expression. Third, L. reuteri-CMVs increased the population of double positive (DP) CD4+CD8+ T cells in the intestinal epithelial layer, suppressing gut inflammation and maintaining gut mucosal homeostasis. Finally, L. reuteri-CMVs exhibited satisfactory stability and safety in the gastrointestinal tract and specifically targeted the desired sites in colitis mice. Collectively, these findings shed light on how L. reuteri interact with the host in colitis, and provide new insights into potential strategies for alleviating colitis. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Nanobiotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis.
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  Data: <searchLink fieldCode="AR" term="%22Yue%2C+Ningning%22">Yue, Ningning</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Hailan%22">Zhao, Hailan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Peng%22">Hu, Peng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yuan%22">Zhang, Yuan</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Chengmei%22">Tian, Chengmei</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kong%2C+Chen%22">Kong, Chen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mai%2C+Zhiliang%22">Mai, Zhiliang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Longbin%22">Huang, Longbin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Qianjun%22">Luo, Qianjun</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Daoru%22">Wei, Daoru</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Ruiyue%22">Shi, Ruiyue</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Shaohui%22">Tang, Shaohui</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nie%2C+Yuqiang%22">Nie, Yuqiang</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liang%2C+Yujie%22">Liang, Yujie</searchLink><relatesTo>9</relatesTo> (AUTHOR)<i> liangyjie@126.com</i><br /><searchLink fieldCode="AR" term="%22Yao%2C+Jun%22">Yao, Jun</searchLink><relatesTo>1,10</relatesTo> (AUTHOR)<i> yj_1108@126.com</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Lisheng%22">Wang, Lisheng</searchLink><relatesTo>1,10</relatesTo> (AUTHOR)<i> wanglsszrmyy@163.com</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Defeng%22">Li, Defeng</searchLink><relatesTo>1,10</relatesTo> (AUTHOR)<i> ldf830712@163.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Nanobiotechnology%22">Journal of Nanobiotechnology</searchLink>. 1/31/2025, Vol. 23 Issue 1, p1-23. 23p.
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  Data: *<searchLink fieldCode="DE" term="%22ULCERATIVE+colitis%22">ULCERATIVE colitis</searchLink><br />*<searchLink fieldCode="DE" term="%22INTESTINAL+barrier+function%22">INTESTINAL barrier function</searchLink><br />*<searchLink fieldCode="DE" term="%22TIGHT+junctions%22">TIGHT junctions</searchLink><br />*<searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br />*<searchLink fieldCode="DE" term="%22GUT+microbiome%22">GUT microbiome</searchLink><br />*<searchLink fieldCode="DE" term="%22PROBIOTICS%22">PROBIOTICS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Probiotics have been proposed as a potential strategy for managing ulcerative colitis (UC). However, the underlying mechanisms mediating microbiota-host crosstalk remain largely elusive. Here, we report that Limosilactobacillus reuteri (L. reuteri), as a probiotic, secretes cytoplasmic membrane vesicles (CMVs) that communicate with host cells, alter host physiology, and alleviate dextran sulfate sodium (DSS)-induced colitis. First, L. reuteri-CMVs selectively promoted the proliferation of the beneficial bacterium Akkermansia muciniphila (AKK) by upregulating the expression of glycosidases (beta-N-acetylhexosaminidase and alpha-N-acetylglucosaminidase) involved in glycan degradation and metabolic pathways and restored the disrupted gut microbiota balance. Second, L. reuteri-CMVs were taken up by intestinal epithelial cells (IECs), elevated the expression of ZO-1, E-cadherin (Cdh1), and Occludin (Ocln), decreased intestinal permeability, and exerted protective effects on epithelial tight junction functionality. RNA sequencing analysis demonstrated that L. reuteri-CMVs repaired intestinal barrier by activating the HIF-1 signaling pathway and upregulating HMOX1 expression. Third, L. reuteri-CMVs increased the population of double positive (DP) CD4+CD8+ T cells in the intestinal epithelial layer, suppressing gut inflammation and maintaining gut mucosal homeostasis. Finally, L. reuteri-CMVs exhibited satisfactory stability and safety in the gastrointestinal tract and specifically targeted the desired sites in colitis mice. Collectively, these findings shed light on how L. reuteri interact with the host in colitis, and provide new insights into potential strategies for alleviating colitis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Nanobiotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1186/s12951-025-03158-8
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        Text: English
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