Bibliographic Details
| Title: |
En la búsqueda de la nefroprotección. Los pilares del tratamiento 2024. |
| Alternate Title: |
In the pursuit of nephroprotection. The pillars of the 2024 treatment. |
| Authors: |
Inserra, Felipe1 felipe.inserra@gmail.com |
| Source: |
Revista de Nefrología Diálisis y Trasplante. 2024, Vol. 44 Issue 4, p211-222. 12p. |
| Subject Terms: |
*TYPE 2 diabetes, *MINERALOCORTICOID receptors, *CHRONIC kidney failure, *RENIN-angiotensin system, *KIDNEY diseases |
| Abstract (English): |
Chronic kidney disease has, after almost 20 years of "status quo," made significant progress in terms of nephroprotection. In the last five years, in addition to the already consolidated renal protection provided by drugs that block the renin-angiotensin system, three other strategies have been added that have confirmed significant benefits for the kidney and its functionality. These are type 2 inhibitors of sodium-glucose co-transport, mineralocorticoid receptor antagonists, particularly non-steroidal ones, and recently GLP-1 receptor agonists. The latter two strategies have solid evidence of kidney disease secondary to type 2 diabetes mellitus for now. This review describes the main results that support their effects and indications for these drugs. These support the growing consensus on their combined use as pillars of nephroprotective treatment. It is possible that with new results and an understanding of how to associate these strategies with each patient or clinical phenotype preferentially, we can obtain increasing benefits to significantly change the course of CKD. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
La enfermedad renal crónica tiene, luego de casi 20 años de "status quo", importantes progresos en términos de nefro protección. En los últimos 5 años se han sumado, a la ya consolidada protección renal brindada por las drogas que bloquean el Sistema Renina Angiotensina, otras tres estrategias que han confirmado beneficiosos significativos sobre el riñón y su funcionalidad. Ellas son: los inhibidores tipo 2 del co-trasporte sodioglucosa, los antagonistas del receptor mineralocorticoide, particularmente los no esteroideos, y recientemente los agonistas del receptor GLP-1. Estos dos últimos con evidencias sólidas en la enfermedad renal secundaria a diabetes mellitus tipo 2 por ahora. Esta revisión describe los principales resultados que avalan sus efectos e indicaciones de estas drogas. Los mismos dan soporte al creciente consenso en su uso combinado a maneras de pilares del tratamiento nefroprotector. Es posible que con nuevos resultados y entendimiento de como asociar, de manera preferente, estas estrategias en cada paciente o fenotipo clínico podamos obtener beneficios crecientes para cambiar significativamente el rumbo de la ERC. [ABSTRACT FROM AUTHOR] |
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