Bibliographic Details
| Title: |
Can Salivary Cortisol be Used in Diagnosing Adrenal Insufficiency During the Acute and Subacute Phases of Traumatic Brain Injury? |
| Authors: |
Urhan, Emre1 (AUTHOR), Elbuken, Gulsah2 (AUTHOR) gelbuken@nku.edu.tr, Karaca, Zuleyha1 (AUTHOR), Unluhizarci, Kursad1 (AUTHOR), Kula, Mustafa3 (AUTHOR), Selcuklu, Ahmed4 (AUTHOR), Kelestimur, Fahrettin5 (AUTHOR) |
| Source: |
Experimental & Clinical Endocrinology & Diabetes. Jan2025, Vol. 133 Issue 1, p25-33. 9p. |
| Subject Terms: |
*BRAIN injuries, *ADRENOCORTICOTROPIC hormone, *ADRENAL insufficiency, *HYPOTHALAMIC-pituitary-adrenal axis, *BIOMARKERS |
| Abstract: |
Introduction The diagnosis of adrenal insufficiency (AI) related to traumatic brain injury (TBI) remains a challenge. We investigated the basal and low-dose adrenocorticotropic hormone (ACTH)-stimulated serum cortisol and salivary cortisol (SaC) levels and the diagnostic utility of SaC levels during 28 days following TBI. Materials and Methods Blood samples were collected for basal levels [sequentially from day 1 (D1) to D7 and on D28)] and for peak serum cortisol and SaC responses to the low-dose ACTH stimulation test (on D1, D7, and D28). After the patient enrollment period was completed, patients were retrospectively categorized as AI or AS (adrenal sufficiency) for each day separately, based on a basal serum cortisol cut-off level of 11 µg/dL, and data analysis was performed between the groups. Results Thirty-seven patients and 40 healthy controls were included. Median basal serum cortisol levels were higher in patients on D1 but were similar on other days. Median basal SaC levels were higher in patients on D1 and D2 but were similar on other days. Median peak serum cortisol and SaC levels were similar on D1 but were lower in patients on D7 and D28. Median basal SaC levels were higher in the AS group than in the AI group on all days. Discussion and Conclusions When evaluating AI during the course of TBI, the cut-off for basal SaC levels is 0.5–0.6 µg/dL throughout the first week, except for 1.38 µg/dL on D2. SaC levels may serve as a surrogate marker for accurately reflecting circulating glucocorticoid activity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Experimental & Clinical Endocrinology & Diabetes is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
