Bibliographic Details
| Title: |
Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study. |
| Authors: |
Das, Rashmi R.1 (AUTHOR) rrdas05@gmail.com, Mangaraj, Manaswini2 (AUTHOR), Nayak, Saurav2 (AUTHOR), Satapathy, Amit K.1 (AUTHOR), Mahapatro, Samarendra1 (AUTHOR) |
| Source: |
Journal of Family Medicine & Primary Care. Jan2025, Vol. 14 Issue 1, p254-258. 5p. |
| Subject Terms: |
*OVERWEIGHT children, *CHILDHOOD obesity, *ACANTHOSIS nigricans, *BODY mass index, *HYPERINSULINISM |
| Abstract: |
ABSTRACT: Background: Acanthosis nigricans (AN) is a common finding often associated with hyperinsulinemia and childhood obesity. There has been a lack of studies evaluating the association of AN with underlying cardio-metabolic risk factors in children and adolescents. Our objective was to study the association between AN and cardio-metabolic risk factors in children with overweight/obesity. Methods: This cross-sectional study included school-going children (6–16 years of age) with overweight/obesity. Physical examination, anthropometry, and blood pressure (BP) data were collected. Fasting blood samples were collected to measure insulin, glucose, homeostasis model assessment index (HOMAIR), and lipid profile. Results: Of 1930 children screened, 545 had overweight/obesity, and were included. Boys to girls ratio was 1.27. AN was present in 46.4% of children. Children with AN had higher body mass index [BMI] (P < 0.01), waist circumference [WC] (P < 0.01), systolic (P = 0.03), and diastolic BP (P = 0.02), hyperglycemia (P = 0.02), hyperinsulinemia (P < 0.01), and a higher HOMA-IR (P < 0.01) compared to those without AN. HDL level was lower in children with AN. Conclusions: Children with overweight/obesity who have AN have significant elevations of BP, insulin level, and HOMA-IR. AN is a clinical marker that seems to be associated with cardio-metabolic risk factors in children with overweight/obesity in the given study population. [ABSTRACT FROM AUTHOR] |
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