| Title: |
N -Alkyl Isofagomine Lactams: Synthesis, Glycosidase Inhibition, and Antimicrobial Assessments. |
| Authors: |
Moreń, Monika1 (AUTHOR), Pereira Lourenço, Ana Laura2,3 (AUTHOR), Cerdà-Cuéllar, Marta2,3 (AUTHOR), Kochanowski, Karl2,3 (AUTHOR), Jørgensen, Kåre B.1 (AUTHOR), Sydnes, Magne O.1,4 (AUTHOR), López, Óscar5 (AUTHOR) osc-lopez@us.es, Lindbäck, Emil1 (AUTHOR) emil.lindback@uis.no |
| Source: |
Synthesis. Feb2025, Vol. 57 Issue 3, p684-694. 11p. |
| Subject Terms: |
*GLYCOSIDASE inhibitors, *LACTAM derivatives |
| Abstract: |
A series of six N -alkyl isofagomine lactam derivatives is synthesized over ten steps from d -arabinose. The compounds are evaluated as glycosidase inhibitors. It was found that the N -alkyl groups have a detrimental effect on the glycosidase inhibition activities, as the prepared N -alkyl isofagomine lactam derivatives are much less potent glycosidase inhibitors than native isofagomine lactam. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Complete |
