Bibliographic Details
| Title: |
Economic evaluation of tenofovir disoproxil fumarate prophylaxis to prevent mother-to-child transmission of Hepatitis B virus infection: evidence from a lower-middle income country. |
| Authors: |
Nguyen, Ha T.1,2 (AUTHOR), Chaikledkaew, Usa1,3 (AUTHOR) usa.chi@mahidol.ac.th, Hoang, Minh V.4 (AUTHOR), Tran, Viet Q.5 (AUTHOR), Thavorncharoensap, Montarat1,3 (AUTHOR), Praditsitthikorn, Naiyana6 (AUTHOR), Tran, Quang D.7 (AUTHOR), Thakkinstian, Ammarin1,8 (AUTHOR) |
| Source: |
BMC Health Services Research. 12/28/2024, Vol. 24 Issue 1, p1-10. 10p. |
| Subject Terms: |
*HEPATITIS B, *VERTICAL transmission (Communicable diseases), *PUBLIC health, *HEPATITIS B virus, *COST effectiveness |
| Geographic Terms: |
VIETNAM |
| Abstract: |
No cost-effectiveness information of preventive strategies for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) has existed for policy decision making. This study aimed to compare the cost-effectiveness of alternative strategies to prevent MTCT of HBV in Vietnam. Cost-utility analysis using a hybrid decision-tree and Markov model were performed from healthcare system and societal perspectives. Preventive strategies included HBV universal vaccination (S1), hepatitis B immunoglobulin (HBIG) for infants of mothers with HBeAg(+) (S2), HBIG for infants of mothers with HBsAg(+) (S3), tenofovir disoproxil fumarate (TDF) for mothers with high viral load (S4) and mothers with HBeAg(+) (S5), and the current practice (S6) with HBV vaccine in all infants and TDF for high viral load mothers. The current practice was dominant to all preventive strategies with interventions in only infants for both perspectives. In contrast, the strategies S4 and S5 were dominant to the current practice with incremental net monetary benefit varying from $33.94 to $70.64 under a healthcare system perspective and from $44.22 to $93.71 under a societal perspective. Addition of HBIG in infants born to mothers infected HBV and tenofovir prophylaxis for mothers with positive HBeAg was the most cost-effective strategy to prevent vertical transmission of HBV in Vietnam. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Health Services Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
