| Title: |
Telomerase activity, telomere length, and the euploidy rate of human embryos. |
| Authors: |
Longo, Maria1 (AUTHOR), Greco, Ermanno2,3 (AUTHOR), Listorti, Ilaria2 (AUTHOR), Varricchio, Maria Teresa2 (AUTHOR), Litwicka, Katerina2 (AUTHOR), Arrivi, Cristiana2 (AUTHOR), Mencacci, Cecilia2 (AUTHOR), Greco, Pierfrancesco2 (AUTHOR) p.greco753@gmail.com |
| Source: |
Gynecological Endocrinology. Dec2024, Vol. 40 Issue 1, p1-6. 6p. |
| Subject Terms: |
*OVARIAN reserve, *GRANULOSA cells, *PREMATURE ovarian failure, *INDUCED ovulation, *HUMAN embryos |
| Abstract: |
Background: Telomeres maintain chromosome stability, while telomerase counteracts their progressive shortening. Telomere length varies between cell types, with leukocyte telomere length (LTL) decreasing with age. Reduced telomerase activity has been linked to reproductive issues in females, such as low pregnancy rates and premature ovarian failure, with recent studies indicating correlations between telomere length in granulosa cells and IVF outcomes. Objectives: The study aims to explore the relationship between telomere length, telomerase activity, and euploid blastocyst rate in infertile women undergoing IVF/ICSI PGT-A cycles. Methods: This prospective study involves 108 patients undergoing controlled ovarian stimulation and PGT-A. Telomere length and telomerase activity were measured in peripheral mononuclear cells and granulosa cells (GC), respectively. Results: The telomere repeat copy number to single gene copy number ratio (T/S) results respectively 0.6 ± 0.8 in leukocytes and 0.7 ± 0.9 in GC. An inverse relationship was found between LTL and the patient's age (p <.01). A higher aneuploid rate was noticed in patients with short LTL, with no differences in ovarian reserve markers (p =.15), number of oocytes retrieved (p =.33), and number of MII (p = 0.42). No significant association was noticed between telomere length in GC and patients' age (p = 0.95), in ovarian reserve markers (p = 0.32), number of oocytes retrieved (p =.58), number of MII (p =.74) and aneuploidy rate (p =.65). Conclusion: LTL shows a significant inverse correlation with patient age and higher aneuploidy rates. Telomere length in GCs does not correlate with patient age or reproductive outcomes, indicating differential telomere dynamics between leukocytes and granulosa cells. [ABSTRACT FROM AUTHOR] |
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