Bibliographic Details
| Title: |
Synergistic Effect of Caloric Restriction and Cyclooxygenase-2 Inhibitor "Celecoxib" Against IGFs/COX-2 Mediating Chemically Induced Hepatocellular Carcinoma in Rats. |
| Alternate Title: |
Efecto Sinérgico de la Restricción Calórica y el Inhibidor de la Ciclooxigenasa-2 "Celecoxib" Contra los IGF/COX-2 que Median el Carcinoma Hepatocelular Inducido Químicamente en Ratas. |
| Authors: |
ShamsEldeen, Asmaa Mohammed1, El Hamzawy, Magda1, Aboulhoda, Basma Emad2, Rashed, Laila3, Alghamdi, Mansour4,5, Hassan, Fatma E.1,6 Fatma.e.elsayed@kasralainy.edu.eg |
| Source: |
International Journal of Morphology. 2024, Vol. 42 Issue 6, p1628-1637. 10p. |
| Subject Terms: |
*CYCLOOXYGENASE 2 inhibitors, *LOW-calorie diet, *SUBCUTANEOUS injections, *PATHOLOGICAL physiology, *HEPATOCELLULAR carcinoma |
| Abstract (English): |
Caloric restriction (CR) alongside its ability to increase longevity, exerts inhibitory effects against various tumors. The purpose of this current research was to investigate the conceivable implications of CR, either independently or in conjunction with a cyclooxygenase 2 inhibitor (Celecoxib), on the pathophysiology of induced hepatocellular carcinoma (HCC). Forty adult male Wistar rats were allocated into four groups: Control, HCC; induced by injecting diethylnitrosamine intraperitoneally, then subsequently given a weekly subcutaneous injection of carbon tetrachloride (CCl4) once a week for 6 consecutive weeks, CR group, and CR-Celecoxib group. The results revealed enhanced serum insulin growth factor-I (IGF-I) and- II (IGF-II) levels, along with a significant increase in COX-2 and IL-6 gene expression as well as acceleration of pathological changes, glycogen depletion, enhanced fibrosis, and decreased caspase 3 expression in the liver. However, both IGF-I, II, and alpha-fetoprotein (AFP) were significantly decreased in the CR group co-treated with Celecoxib which was positively reflected on the liver architecture. We concluded that combined CR and COX-2 inhibition interferes with the pathogenesis of HCC. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
La restricción calórica (RC), junto con su capacidad para aumentar la longevidad, ejerce efectos inhibidores contra varios tumores. El propósito de esta investigación actual fue investigar las posibles implicaciones de la RC, ya sea de forma independiente o junto con un inhibidor de la ciclooxigenasa 2 (Celecoxib), en la fisiopatología del carcinoma hepatocelular inducido (CHC). Cuarenta ratas Wistar macho adultas se dividieron en cuatro grupos: Control, CHC; inducido mediante inyección intraperitoneal de dietilnitrosamina, luego se le administró una inyección subcutánea semanal de tetracloruro de carbono (CCl4) una vez por semana durante 6 semanas consecutivas, grupo CR y grupo CR-Celecoxib. Los resultados revelaron niveles mejorados de factor de crecimiento insulínico sérico I (IGF-I) y II (IGF-II), junto con un aumento significativo en la expresión de los genes COX-2 e IL-6, así como aceleración de cambios patológicos, depleción de glucógeno, fibrosis mejorada y disminución de la expresión de caspasa 3 en el hígado. Sin embargo, tanto IGF-I, II como alfa-fetoproteína (AFP) disminuyeron significativamente en el grupo CR co-tratado con Celecoxib, lo que se reflejó positivamente en la arquitectura hepática. Concluimos que la inhibición combinada de CR y COX-2 interfiere con la patogénesis del CHC. [ABSTRACT FROM AUTHOR] |
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