| Title: |
The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring. |
| Authors: |
Chae, Jiwon1 (AUTHOR), Choi, Mina2 (AUTHOR), Choi, Juyoung2 (AUTHOR), Yoo, Seung-Jun1,3,4,5 (AUTHOR) seungjun@hanyang.ac.kr |
| Source: |
Animal Cells & Systems. Feb2024, Vol. 28 Issue 1, p45-54. 10p. |
| Subject Terms: |
*CRIBRIFORM plate, *CENTRAL nervous system, *OLFACTORY nerve, *CEREBROSPINAL fluid, *NEURODEGENERATION |
| Abstract: |
Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Among the various CSF outflow pathways, the route through the cribriform plate along the olfactory nerves stands out as the most predominant. This review describes the outflow pathway of CSF into the nasal lymphatics. Additionally, we examine existing studies to describe mutual influences observed between the brain and extracranial regions due to this outflow pathway. Notably, pathological conditions in the CNS often influence CSF outflow, leading to observable changes in extracranial regions. The established connection between the brain and the nose is significant, and our review underscores its potential relevance in monitoring CNS ailments, including neurodegenerative diseases. Considering that aging – the most significant risk factor for the onset of neurodegeneration – is also a principal factor in CSF turnover alterations, we suggest a novel approach to studying neurodegenerative diseases in therapeutic terms. [ABSTRACT FROM AUTHOR] |
|
Copyright of Animal Cells & Systems is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
