Bibliographic Details
| Title: |
BOPHY Derivatives as Phototherapeutic Agents for the Photodynamic Inactivation of Microorganisms. |
| Authors: |
Chávez Hernández, Claudia1 (AUTHOR), Palacios, Yohana B.1 (AUTHOR), Gonzalez Lopez, Edwin J.1 (AUTHOR), Lopez, Maribel1 (AUTHOR), Durantini, Edgardo N.1,2 (AUTHOR), Durantini, Andrés M.3 (AUTHOR), Agazzi, Maximiliano L.1 (AUTHOR) magazzi@exa.unrc.edu.ar, Heredia, Daniel A.1,2 (AUTHOR) dheredia@exa.unrc.edu.ar |
| Source: |
ChemPhotoChem. Dec2024, Vol. 8 Issue 12, p1-13. 13p. |
| Subject Terms: |
*FLUORESCENCE yield, *PATHOGENIC microorganisms, *BACTERIAL inactivation, *PHOTOSENSITIZERS, *RADICAL anions, *REACTIVE oxygen species, *METHICILLIN-resistant staphylococcus aureus |
| Abstract: |
The improvement of photodynamic inactivation (PDI) significantly depends on the development of new families of photosensitizers (PSs). In this sense, three BOPHY derivatives (BP, BP‐Br and BP‐I) were synthetized, studied, and compared to assess their antimicrobial photodynamic properties. BP is an interesting fluorescent probe for cell imaging, while the halogenated analogs (BP‐Br and BP‐I) are excellent oxygen photosensitizing agents. BP compound presented a fluorescence quantum yield close unity and showed no reactive oxygen species (ROS) production. In contrast, BP‐I did not show emission properties but exhibited a high production of ROS through both photodynamic mechanisms, generating singlet oxygen (type II) and superoxide radical anion (type I) under aerobic light irradiation. BP‐Br presented an adequate balance between ROS production and emission properties. The photokilling action and the binding to bacterial cells of these macrocycles were evaluated in vitro against methicillin‐resistant Staphylococcus aureus (MRSA) and Escherichia coli bacteria. Our results demonstrated that the halogenated BOPHY derivatives were effective PSs in inactivating MRSA using shorter irradiation periods. In addition, the antimicrobial action sensitized by these BOPHYs was potentiated by adding KI. The combination of halogenated BOPHY and KI led to a complete elimination of both Gram‐positive and Gram‐negative bacteria. Hence, BP‐Br and BP‐I prove to be potent broad‐spectrum antimicrobial PSs. To the best of our knowledge, this is the first time that BOPHY derivatives have been applied to photokill pathogenic microorganisms. [ABSTRACT FROM AUTHOR] |
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| Database: |
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