Bibliographic Details
| Title: |
Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation. |
| Authors: |
Udrea, Ana Maria1,2,3 (AUTHOR), Staicu, Angela1 (AUTHOR) angela.staicu@inflpr.ro, Smarandache, Adriana1 (AUTHOR), Andrei, Ionut Relu1 (AUTHOR), Badea, Madalina Andreea4 (AUTHOR), Avram, Speranta3 (AUTHOR), Pascu, Mihail Lucian1,5 (AUTHOR), Pirvulescu, Ruxandra Angela6 (AUTHOR), Balas, Mihaela4 (AUTHOR) mihaela.balas@bio.unibuc.ro |
| Source: |
Scientific Reports. 12/5/2024, Vol. 14 Issue 1, p1-16. 16p. |
| Subject Terms: |
*DRUG repositioning, *MEDICAL sciences, *BREAST cancer, *FOURIER transform infrared spectroscopy, *MOLECULAR structure |
| Abstract: |
Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser irradiation for varying durations, characterized by UV-Vis and FTIR spectroscopy, followed by drug-likeness and ADME-Tox predictions. In vitro assays evaluated the cytotoxicity and cellular effects on MCF-7 breast cancer cells, and compared with MCF-12 A healthy cell line. Laser irradiation altered CPZ molecular structure resulting in photoproducts with favourable drug-like properties and ADME-Tox profiles. In vitro evaluations demonstrate dose and irradiation time-dependent cytotoxicity against breast cancer cells, and reduced toxicity on healthy cell line. Significant alterations in F-actin organization, and excessive ROS generation were also proved, suggesting the potential of laser-modified CPZ for breast cancer therapy. This study introduces a novel approach to breast cancer treatment through laser irradiated CPZ, highlighting promising advancements in therapy and emphasizing the role of laser-generated compounds. [ABSTRACT FROM AUTHOR] |
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