Effect of Combination of Blue and Red Light with Terbinafine on Cell Viability and Reactive Oxygen Species in Human Keratinocytes: Potential Implications for Cutaneous Mycosis.

Bibliographic Details
Title: Effect of Combination of Blue and Red Light with Terbinafine on Cell Viability and Reactive Oxygen Species in Human Keratinocytes: Potential Implications for Cutaneous Mycosis.
Authors: Pérez González, Luis Alfonso1 (AUTHOR) pg.l.alfonso@gmail.com, Martínez-Pascual, María Antonia2 (AUTHOR) m.antonia.martinez@hrc.es, Toledano-Macías, Elena2 (AUTHOR) elena.toledano@hrc.es, Jara-Laguna, Rosa Cristina2 (AUTHOR) rosacristina.jara@salud.madrid.org, Fernández-Guarino, Montserrat1 (AUTHOR) montsefdez@msn.com, Hernández-Bule, María Luisa2 (AUTHOR) montsefdez@msn.com
Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12145. 15p.
Subject Terms: *RED light, *DERMATOMYCOSES, *BLUE light, *REACTIVE oxygen species, *TERBINAFINE
Abstract: Cutaneous mycoses are common infections whose treatment has become more complex due to increasing antifungal resistance and the need for prolonged therapies, hindering patient adherence and increasing the incidence of adverse effects. Consequently, the use of physical therapies, especially photodynamic therapy (PDT), has increased for the treatment of onychomycosis due to its antimicrobial capacity being mediated by the production of reactive oxygen species. This study investigates the in vitro effect of applying blue light (448 nm) or red light (645 nm), alone or together with terbinafine, on the viability of human keratinocytes and the production of reactive oxygen species. The combination of terbinafine and blue light significantly increases ROS production and caspase-3 expression, while red light together with terbinafine increases catalase, superoxide dismutase (SOD) and PPARγ expression, which reduces the amount of ROS in the cultures. The effect of both treatments could be useful in clinical practice to improve the response of cutaneous mycoses to pharmacological treatment, reduce their toxicity and shorten their duration. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
Full text is not displayed to guests.
More Details
ISSN:16616596
DOI:10.3390/ijms252212145
Published in:International Journal of Molecular Sciences
Language:English