Bibliographic Details
| Title: |
Role of Metalloproteinases in Adhesion to Radicular Dentin: A Literature Review. |
| Authors: |
Valdez-Montoya, Marihana1 (AUTHOR) marihanavaldezm@gmail.com, Avendaño-Félix, Mariana Melisa2 (AUTHOR) marianaavendano@uas.edu.mx, Basurto-Flores, Julio César2 (AUTHOR) juliobasurtof@uas.edu.mx, Ramírez-Álvarez, Maricela3 (AUTHOR) dra.maricela_odontologia@uas.edu.mx, Cázarez-Camacho, María del Rosario3 (AUTHOR) mariacazarez@uas.edu.mx, Casillas-Santana, Miguel Ángel4 (AUTHOR) miguel.casillas@correo.buap.mx, Zavala-Alonso, Norma Verónica1 (AUTHOR) nveroza@fest.uaslp.mx, Sarmiento-Hernández, Seyla Nayjaá5 (AUTHOR) seylasarmiento@uas.edu.mx, Silva-Benítez, Erika de Lourdes2 (AUTHOR) erikasilva@uas.edu.mx, Soto-Sainz, Jesús Eduardo2 (AUTHOR) eduardosotosainz@uas.edu.mx |
| Source: |
Materials (1996-1944). Nov2024, Vol. 17 Issue 22, p5674. 17p. |
| Subject Terms: |
*PROTEOLYTIC enzymes, *TISSUE remodeling, *DENTIN, *EXTRACELLULAR matrix, *METALLOPROTEINASES, *ADHESION |
| Abstract: |
Introduction: Root dentin is a porous and complex dental surface that may have irregularities and deposits of organic material. To achieve an effective bond between restorative materials and root dentin, it is necessary that the restorative materials adhere intimately to the dentin surface. Metalloproteinases (MMPs) are a group of proteolytic enzymes that perform an important role in degrading the extracellular matrix and remodeling connective tissue. The aim of this research was to determine the scientific evidence available on the role played by MMPs in adhesion to root dentin and their putative inhibitors. Materials and Methods: Several techniques have been used to evaluate the presence of MMPs in the root dentin of human and bovine teeth, such as Western blot, immunohistochemistry, immunofluorescence, and zymography, the latter also being used together with the EnzCheck assay to evaluate the inhibitory effect of adhesion protocols on the activity of root MMPs in vitro. Results: When analyzing the databases, 236 articles were found, 12 of which met the selection criteria. The variables analyzed were articles that evaluated different MMP inhibitors in root dentin. Conclusions: In the adhesion to radicular dentin, MMPs have a crucial role in the degradation of the extracellular matrix of dentin and the remodeling of the dentin surface because excessive MMP activity can be harmful to dental health, since excessive degradation of the extracellular matrix of dentin can weaken the tooth structure and decrease fracture resistance. Therefore, it is important to monitor MMP activity during root dentin bonding procedures. [ABSTRACT FROM AUTHOR] |
|
Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
