| Title: |
Evaluation of the cross section data for cyclotron production of medical radionuclides 201Pb→201Tl and 203Pb. |
| Authors: |
Samar1 (AUTHOR), Amjed, N.1 (AUTHOR) noumanamjad@ue.edu.pk, Naz, A.2 (AUTHOR), Wajid, A.M.3 (AUTHOR), Eman, M.1 (AUTHOR), Saeed, M.A.1 (AUTHOR) |
| Source: |
Radiation Physics & Chemistry. Jan2025, Vol. 226, pN.PAG-N.PAG. 1p. |
| Subject Terms: |
*NUCLEAR models, *DEUTERON reactions, *LEAD isotopes, *NUCLEAR medicine, *STATISTICS |
| Abstract: |
Lead Isotopes can be effectively used in nuclear medicine, 203Pb forms a theranostic pair with 212Pb whereas 201Pb→ 201Tl, facilitate the production of 201Tl via the generator system. The aim of this work was to achieve the high purity production of 203Pb and 201Tl via a cyclotron. To achieve this, several charged particle induced reactions namely 205Tl(p,3n)203Pb, 205Tl(d,4n)203Pb, 205Tl(p,5n)201Pb→201Tl, 205Tl(d,6n)201Pb→201Tl, 203Tl(p,3n)201Pb→201Tl, and 203Tl(d,4n)201Pb→201Tl were evaluated. First the consistency and reliability of the experimental data were ensured by using established nuclear model codes like TALYS 1.9 and EMPIRE 3.2. A robust methodology, based on experimental data and theoretical nuclear models, was used to generate the recommended cross sections for each production route and associated radioisotopic impurities. The thick target yields were calculated for each production route and its corresponding impurity reaction by utilizing the recommended/reference data. Following a thorough analysis and comparison of the evaluated production routes, it was concluded that the most promising options are 205Tl(d,4n)203Pb and 203Tl(p,3n)201Pb→201Tl. Their optimum conditions were determined as E d = 30 → 21 MeV and Ep = 30 → 21 MeV with integral yields of 568.9 MBq/μAh and 1223.5 MBq/μAh respectively. • Evaluation of excitation functions of proton and deuteron induced reactions on targets 203Tl and 205Tl. • Statistical adjustment of the data and nuclear model calculations (TALYS 1.9, ALICE-IPPE, and EMPIRE 3.2). • Integral yield and impurity estimation in the production of 201Pb.→201Tl and 203Pb. • Standardisation of cross section data for the production of 201Pb.→201Tl and 203Pb. [ABSTRACT FROM AUTHOR] |
|
Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
