Bibliographic Details
| Title: |
Two Regions with Different Expression of Lipogenic Enzymes in Rats' Posterior Subcutaneous Fat Depot. |
| Authors: |
Turyn, Jacek1 (AUTHOR) ewa.stelmanska@gumed.edu.pl, Stelmanska, Ewa1 (AUTHOR), Szrok-Jurga, Sylwia1 (AUTHOR) jacek.turyn@gumed.edu.pl |
| Source: |
International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11546. 12p. |
| Subject Terms: |
*FATTY acid synthases, *BROWN adipose tissue, *WHITE adipose tissue, *UNCOUPLING proteins, *BUTTOCKS, *ADIPOSE tissues |
| Abstract: |
Lipid metabolism in various adipose tissue depots can differ vastly. This also applies to lipogenesis, the process of synthesizing fatty acids from acetyl-CoA. This study compared the expression of some lipogenic enzymes: fatty acid synthase (FASN), ATP-citrate lyase (ACLY), and malic enzyme 1 (ME1) in different regions of the posterior subcutaneous adipose tissue in rats. Methods and Results: Posterior subcutaneous adipose tissue collected from twelve-month-old Wistar rats was divided into six parts (A–F). The expression of genes encoding lipogenic enzymes was assessed by measuring their activity and mRNA levels using real-time PCR. In the gluteal region of the fat pad, there were much higher levels of activity and mRNA for these lipogenic enzymes compared to the dorsolumbar region. The mRNA level of FASN increased by more than twentyfold, whereas the level of ME1 and ACLY increased eight- and fivefold respectively. This phenomenon was observed in both old and young animals. Furthermore, the lack of uncoupling protein one (Ucp1) expression suggests that neither the presence of brown adipocytes in the gluteal part nor the transformation of white adipocytes into beige contributed to the observed differences. Conclusion: These results indicate that the gluteal white adipose tissue appears to be a unique and separate subcutaneous fat depot. [ABSTRACT FROM AUTHOR] |
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