Bibliographic Details
| Title: |
Challenges in neonatal care: a case report of purpura fulminans in a 10-day-old infant. |
| Authors: |
Sohail, Huma1 (AUTHOR), Zafar, Yumna1 (AUTHOR) yumii.zafar0505@gmail.com, Syed, Dua Irshad1 (AUTHOR), Jamal, Ammarah2 (AUTHOR), Lail, Amanullah2 (AUTHOR) |
| Source: |
Egyptian Pediatric Association Gazette. 10/4/2024, Vol. 72 Issue 1, p1-5. 5p. |
| Subject Terms: |
*PROTEIN S deficiency, *BLOOD diseases, *BLOOD coagulation disorders, *PROTEIN C, *RESOURCE-limited settings |
| Abstract: |
Background: Purpura fulminans (PF) is a rare but severe thrombotic disorder affecting small cutaneous blood vessels. It may present as bruising and discoloration but can rapidly progress necrosis and life-threatening complications if not promptly diagnosed and treated. This paper presents a rare case of neonatal PF associated with protein C and S deficiency, highlighting the importance of prompt recognition and diagnosis. Case presentation: A 10-day-old male infant presented with extensive purpura fulminans, microcephaly, and craniofacial abnormalities. Laboratory investigations revealed severe deficiencies in protein C, protein S, and antithrombin III. Treatment involved a multidisciplinary approach including antibiotic therapy, blood transfusions, and anticoagulation. Discussion: Neonatal PF poses significant challenges due to its high mortality rate and potential neurological complications. Prompt diagnosis and management are crucial, although outcomes can vary. Long-term care and genetic counseling are essential for families affected by this rare disorder. Conclusion: This case underscores the importance of early recognition and intervention in neonatal PF, especially in resource-limited settings. Improved strategies for diagnosis, management, and patient education are necessary to enhance outcomes and support affected families. [ABSTRACT FROM AUTHOR] |
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| Database: |
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