| Title: |
Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them. |
| Authors: |
Don, Elena1 (AUTHOR) gavrilovaes@materiamedica.ru, Zakharova, Svetlana1 (AUTHOR), Yaroshenko, Sabina1 (AUTHOR), Petrova, Anastasia1 (AUTHOR), Tarasov, Sergey1,2 (AUTHOR) |
| Source: |
Dose-Response. Jul-Sep2024, Vol. 22 Issue 3, p1-10. 10p. |
| Subject Terms: |
*CHO cell, *INSULIN antibodies, *RECEPTOR antibodies, *AQUEOUS solutions, *DILUTION |
| Abstract: |
Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution's activity. In the framework of this article, a statistically significant effect of TP antibodies to the insulin receptor on glucose consumption by CHO cells both with and without contact exposure, as compared with control (P < 0.05) was shown in the vast majority of the experiments. The obtained results shed light on a possible source of activity of drugs based on TP antibodies, which should be associated with the applied vibration effect and can manifest itself both with contact exposure and without it. [ABSTRACT FROM AUTHOR] |
|
Copyright of Dose-Response is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
