PI3K/AKT/mTOR Signaling Network in Human Health and Diseases.
| Title: | PI3K/AKT/mTOR Signaling Network in Human Health and Diseases. |
|---|---|
| Authors: | Omolekan, Tolulope O.1,2,3 (AUTHOR) tolulope.omolekan@bowen.edu.ng, Chamcheu, Jean Christopher1,2,4 (AUTHOR) jchamcheu@lsu.edu, Buerger, Claudia5 (AUTHOR) jchamcheu@lsu.edu, Huang, Shile6,7,8 (AUTHOR) jchamcheu@lsu.edu |
| Source: | Cells (2073-4409). Sep2024, Vol. 13 Issue 17, p1500. 8p. |
| Subject Terms: | *SCIENTIFIC literature, *PLATELET-derived growth factor receptors, *GENE expression, *TRANSCRIPTION factors, *PROTEIN kinase B, *DNA repair, *EXTRACELLULAR signal-regulated kinases, KERATINOCYTE differentiation |
| Abstract: | The article discusses the PI3K/AKT/mTOR signaling network and its role in human health and diseases. Dysregulation of this pathway is associated with various diseases, including cancer, infections, inflammation, and neurological, metabolic, and cardiovascular disorders. The article emphasizes the importance of understanding this signaling network to develop targeted therapies for conditions like cancer, neurodegenerative disorders, inflammation, autoimmune diseases, obesity, and diabetes. Specific studies are mentioned that investigate the role of this pathway in diseases such as colorectal cancer, psoriasis, breast cancer, progressive multifocal leukoencephalopathy, and osteonecrosis of the femoral head. The article concludes that a comprehensive understanding of this pathway is crucial for managing human health and diseases effectively. [Extracted from the article] |
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| Items | – Name: Title Label: Title Group: Ti Data: PI3K/AKT/mTOR Signaling Network in Human Health and Diseases. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Omolekan%2C+Tolulope+O%2E%22">Omolekan, Tolulope O.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> tolulope.omolekan@bowen.edu.ng</i><br /><searchLink fieldCode="AR" term="%22Chamcheu%2C+Jean+Christopher%22">Chamcheu, Jean Christopher</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<i> jchamcheu@lsu.edu</i><br /><searchLink fieldCode="AR" term="%22Buerger%2C+Claudia%22">Buerger, Claudia</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> jchamcheu@lsu.edu</i><br /><searchLink fieldCode="AR" term="%22Huang%2C+Shile%22">Huang, Shile</searchLink><relatesTo>6,7,8</relatesTo> (AUTHOR)<i> jchamcheu@lsu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Cells+%282073-4409%29%22">Cells (2073-4409)</searchLink>. Sep2024, Vol. 13 Issue 17, p1500. 8p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22SCIENTIFIC+literature%22">SCIENTIFIC literature</searchLink><br />*<searchLink fieldCode="DE" term="%22PLATELET-derived+growth+factor+receptors%22">PLATELET-derived growth factor receptors</searchLink><br />*<searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br />*<searchLink fieldCode="DE" term="%22TRANSCRIPTION+factors%22">TRANSCRIPTION factors</searchLink><br />*<searchLink fieldCode="DE" term="%22PROTEIN+kinase+B%22">PROTEIN kinase B</searchLink><br />*<searchLink fieldCode="DE" term="%22DNA+repair%22">DNA repair</searchLink><br />*<searchLink fieldCode="DE" term="%22EXTRACELLULAR+signal-regulated+kinases%22">EXTRACELLULAR signal-regulated kinases</searchLink><br /><searchLink fieldCode="DE" term="%22KERATINOCYTE+differentiation%22">KERATINOCYTE differentiation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article discusses the PI3K/AKT/mTOR signaling network and its role in human health and diseases. Dysregulation of this pathway is associated with various diseases, including cancer, infections, inflammation, and neurological, metabolic, and cardiovascular disorders. The article emphasizes the importance of understanding this signaling network to develop targeted therapies for conditions like cancer, neurodegenerative disorders, inflammation, autoimmune diseases, obesity, and diabetes. Specific studies are mentioned that investigate the role of this pathway in diseases such as colorectal cancer, psoriasis, breast cancer, progressive multifocal leukoencephalopathy, and osteonecrosis of the femoral head. The article concludes that a comprehensive understanding of this pathway is crucial for managing human health and diseases effectively. [Extracted from the article] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/cells13171500 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1500 Subjects: – SubjectFull: SCIENTIFIC literature Type: general – SubjectFull: PLATELET-derived growth factor receptors Type: general – SubjectFull: GENE expression Type: general – SubjectFull: TRANSCRIPTION factors Type: general – SubjectFull: PROTEIN kinase B Type: general – SubjectFull: DNA repair Type: general – SubjectFull: EXTRACELLULAR signal-regulated kinases Type: general – SubjectFull: KERATINOCYTE differentiation Type: general Titles: – TitleFull: PI3K/AKT/mTOR Signaling Network in Human Health and Diseases. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Omolekan, Tolulope O. – PersonEntity: Name: NameFull: Chamcheu, Jean Christopher – PersonEntity: Name: NameFull: Buerger, Claudia – PersonEntity: Name: NameFull: Huang, Shile IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20734409 Numbering: – Type: volume Value: 13 – Type: issue Value: 17 Titles: – TitleFull: Cells (2073-4409) Type: main |
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