Bibliographic Details
| Title: |
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases. |
| Authors: |
Omolekan, Tolulope O.1,2,3 (AUTHOR) tolulope.omolekan@bowen.edu.ng, Chamcheu, Jean Christopher1,2,4 (AUTHOR) jchamcheu@lsu.edu, Buerger, Claudia5 (AUTHOR) jchamcheu@lsu.edu, Huang, Shile6,7,8 (AUTHOR) jchamcheu@lsu.edu |
| Source: |
Cells (2073-4409). Sep2024, Vol. 13 Issue 17, p1500. 8p. |
| Subject Terms: |
*SCIENTIFIC literature, *PLATELET-derived growth factor receptors, *GENE expression, *TRANSCRIPTION factors, *PROTEIN kinase B, *DNA repair, *EXTRACELLULAR signal-regulated kinases, KERATINOCYTE differentiation |
| Abstract: |
The article discusses the PI3K/AKT/mTOR signaling network and its role in human health and diseases. Dysregulation of this pathway is associated with various diseases, including cancer, infections, inflammation, and neurological, metabolic, and cardiovascular disorders. The article emphasizes the importance of understanding this signaling network to develop targeted therapies for conditions like cancer, neurodegenerative disorders, inflammation, autoimmune diseases, obesity, and diabetes. Specific studies are mentioned that investigate the role of this pathway in diseases such as colorectal cancer, psoriasis, breast cancer, progressive multifocal leukoencephalopathy, and osteonecrosis of the femoral head. The article concludes that a comprehensive understanding of this pathway is crucial for managing human health and diseases effectively. [Extracted from the article] |
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| Database: |
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