Bibliographic Details
| Title: |
Novel Pestiviruses Detected in Cattle Interfere with Bovine Viral Diarrhea Virus Diagnostics. |
| Authors: |
Köster, Judith1 (AUTHOR) judith.koester@stuaau.bwl.de, Schneider, Karla1 (AUTHOR), Höper, Dirk2 (AUTHOR), Salditt, Andreas1 (AUTHOR), Beer, Martin2 (AUTHOR), Miller, Thomas1 (AUTHOR), Wernike, Kerstin2 (AUTHOR) |
| Source: |
Viruses (1999-4915). Aug2024, Vol. 16 Issue 8, p1301. 11p. |
| Subject Terms: |
*BOVINE viral diarrhea virus, *BOVINE viral diarrhea, *WHOLE genome sequencing, *TEST systems, *SEQUENCE analysis |
| Abstract: |
Since the start of the mandatory nationwide bovine viral diarrhea (BVD) eradication program in Germany in 2011, the number of persistently infected (PI) animals has decreased considerably, resulting in a continuous decrease in seroprevalence. The increasingly BVD-naive cattle population could facilitate spillover infections with non-BVDV ruminant pestiviruses. Here, we report two cases in which novel pestiviruses were isolated from cattle; in both cases, the whole genome sequence showed the highest level of identity to strain "Pestivirus reindeer-1". Both novel viruses gave positive results in BVDV diagnostic test systems, confirming that cross-reactivity is an important issue in pestivirus diagnostics. In the first case, the pestivirus was probably transmitted from sheep kept with the affected cattle, suggesting that the co-housing of small ruminants and cattle is a risk factor. The source of infection could not be determined in the second case. The occurrence of these two cases in independent cattle holdings within a relatively short time frame suggests that it would be useful to determine the presence of pestiviruses in small ruminants or even wild ruminants to better assess risk factors, especially for BVDV-free populations. [ABSTRACT FROM AUTHOR] |
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