| Title: |
Morphographic Changes in the Electrocardiogram of Colossoma macropomum Caused by Exposure to Manganese. |
| Authors: |
Nascimento, Lorena Meirelis do1 (AUTHOR) gurgelanthony@gmail.com, dos Santos, Murilo Farias1 (AUTHOR), Paz, Clarissa Araújo da1 (AUTHOR), de Araújo, Daniella Bastos1 (AUTHOR), Ferreira, Rayllan da Cunha1 (AUTHOR), Deiga, Yris da Silva1 (AUTHOR), de Souza, Luana Vasconcelos1 (AUTHOR), Câmara, Tays Mata1 (AUTHOR), dos Santos, Rodrigo Gonçalves1 (AUTHOR), Barbosa, Anara de Sousa1 (AUTHOR), Hamoy, Maria Klara Otake1 (AUTHOR), do Amaral, Anthony Lucas Gurgel1 (AUTHOR), Eiró-Quirino, Luciana1 (AUTHOR) luciana.eiro@ics.ufpa.br, Cabral, Tárcio dos Santos2 (AUTHOR), da Silva, Maria Adrina Paixão de Souza3 (AUTHOR), Muto, Nilton Akio4 (AUTHOR), Hamoy, Moisés1 (AUTHOR) |
| Source: |
International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8910. 11p. |
| Subject Terms: |
*TAMBAQUI, *CRUST of the earth, *EIGENFUNCTIONS, *HEART beat, *CHEMICAL elements |
| Abstract: |
Manganese (Mn2+) is an abundant chemical element in the earth's crust and is present in soil, water, and industrial environments, including mining, welding, and battery manufacturing. Manganese (Mn) is an essential metal needed as a cofactor for many enzymes to maintain proper biological functions. Excessive exposure to Mn in high doses can result in a condition known as manganism, which results in disorders of the neurological, cardiac, and pulmonary systems. The aim of this study was to assess cardiac susceptibility to manganese intoxication in Colossoma macropomum subjected to a fixed concentration of 4 mg/mL for a period of up to 96 h. This study used 45 Tambaquis (30.38 ± 3.5 g) divided into five groups of 9 animals/treatment. The treated groups were exposed to the manganese concentration for a period of 24, 48, 72, and 96 h, after which the animals' ECGs were recorded, showing heart rate, R-R interval, P-Q interval, QRS complex duration and S-T interval. The results showed that cardiac activity decreased as the contact time increased, with an increase in the P-Q and S-T intervals. This indicates that the breakdown of circulatory homeostasis in these animals was caused by contact time with manganese. [ABSTRACT FROM AUTHOR] |
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