Bibliographic Details
| Title: |
Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri. |
| Authors: |
You, Jin‐Qiu1,2 (AUTHOR), Jin, Yun‐Qi1,2 (AUTHOR), Li, Meng‐Yu1,2 (AUTHOR), Zhang, Bo‐Chao3 (AUTHOR), Sun, Xin‐Yu4 (AUTHOR), Ding, Chun‐Yong1,2 (AUTHOR), Li, Jing‐Ya4 (AUTHOR), Hou, Ai‐Jun1,2 (AUTHOR) ajhou@sjtu.edu.cn |
| Source: |
Chinese Journal of Chemistry. Sep2024, Vol. 42 Issue 18, p2180-2186. 7p. |
| Subject Terms: |
*HYPERICUM, *NATURAL products, *LIPOPOLYSACCHARIDES, *SKELETON, *INFLAMMATION |
| Abstract: |
Comprehensive Summary: Hyperlanins A (1) and B (2), two highly rearranged polycyclic polyprenylated acylphloroglucinol (PPAP)‐related meroterpenoids based on different new carbon skeletons, were isolated from Hypericum lancasteri. Compound 1 incorporates an unprecedented 5/6/7/5 ring system featuring a 3,13‐dioxatetracyclo[9.2.1.12,5.01,8]pentadecane core. Compound 2 possesses a unique compact 6/6/5/6/6/5/6 ring system with a caged tetracyclo[6.2.1.13,8.05,11]dodecane motif. Their structures were established by spectroscopic data, X‐ray diffraction, and computational approaches. Both compounds showed anti‐inflammatory activity in vitro. Compounds 1 and 2 could decrease the lipopolysaccharide (LPS)‐/nigericin‐induced IL‐1β release in THP‐1 cells. Both compounds also showed inhibition in hypoxia‐inducible factor‐1α (HIF‐1α) pathway luciferase reporter assay. [ABSTRACT FROM AUTHOR] |
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| Database: |
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