Bibliographic Details
| Title: |
Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis. |
| Authors: |
Cicero, Arrigo F. G.1,2 (AUTHOR) arrigo.cicero@unibo.it, ALGhasab, Naif Saad3,4 (AUTHOR) dr.naif.saad@gmail.com, Tocci, Giuliano5 (AUTHOR) giuliano.tocci@uniroma1.it, Desideri, Giovambattista6 (AUTHOR) giovambattista.desideri@uniroma1.it, Fiorini, Giulia1,2 (AUTHOR) arrigo.cicero@unibo.it, Fogacci, Federica1 (AUTHOR) arrigo.cicero@unibo.it |
| Source: |
Journal of Clinical Medicine. Aug2024, Vol. 13 Issue 15, p4572. 15p. |
| Subject Terms: |
*BISOPROLOL, *BLOOD pressure, *HYDROCHLOROTHIAZIDE, *HYPERTENSION, *CONFIDENCE intervals |
| Abstract: |
Objectives: This systematic review and meta-analysis aimed to assess the blood pressure (BP)-lowering effect and the safety profile of low-dose bisoprolol/hydrochlorothiazide combination treatment in patients with hypertension. Methods: Multiple electronic databases were systematically searched, and five clinical studies were included in the meta-analysis. Results: Treatment with bisoprolol/hydrochlorothiazide significantly reduced systolic BP (SBP) [mean difference (MD): −8.35 mmHg, 95% confidence interval (CI): −11.44, −5.25 mmHg versus control; MD: −9.88 mmHg, 95%CI: −12.62, −7.14 mmHg versus placebo] and diastolic BP (DBP) [MD: −7.62 mmHg, 95%CI: −11.20, −4.04 mmHg, versus control; MD: −8.79 mmHg, 95%CI: −11.92, −5.67 mmHg versus placebo]. Moreover, BP response rate and BP control rate after low-dose bisoprolol/hydrochlorothiazide combination treatment were significantly greater compared to control [odd ratio (OR) for response rate: 4.86, 95%CI: 2.52, 9.37; OR for control rate: 1.67, 95%CI: 1.11, 2.51]. Finally, treatment with low-dose bisoprolol/hydrochlorothiazide was associated with a reduced risk of any adverse event (AE) and peripheral edema compared to control. Conclusions: Overall, our results reaffirm the safety and efficiency of prescribing bisoprolol/hydrochlorothiazide combination treatment in stage I and II hypertension. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
