Bibliographic Details
| Title: |
Serum and salivary interleukin-1β level in oral precancer: An observational study. |
| Authors: |
T., Thamarai Selvan1 reechdr.tam@gmail.com, Patil, Ranjit K.1, Singh, Vandana1, Verma, Saurabh2, Tripathi, Anurag1, Khanna, Vikram1, Chaurasia, Akhilanand1, Shetye, Akanksha G.3 |
| Source: |
Journal of Cancer Research & Therapeutics. Apr-Jun2024, Vol. 20 Issue 3, p788-792. 5p. |
| Subject Terms: |
*ORAL submucous fibrosis, *ORAL leukoplakia, *ENZYME-linked immunosorbent assay, *CHI-squared test, *BIOMARKERS |
| Abstract: |
Background and Aim: Precancer biomarkers help in early detection and management of oral potentially malignant disorders(OPMDs). Interleukin-1β (IL-1β), a biomarker, is known to be altered in oral submucous fibrosis (OSMF) and oral leukoplakia (OL). Therefore, we evaluated and compared the serum and salivary IL-1β levels in patients with OSMF/oral leukoplakia and in gender- and age-matched healthy individuals. Materials and Methods: An in vivo, prospective, observational study was conducted on 40 subjects. Subjects were divided into two groups with 20 individuals in each group, that is, Group I: OSMF/oral leukoplakia and Group II: control group. Salivary and serum IL-1β levels were quantitatively estimated using enzyme-linked immunosorbent assay (ELISA). The statistical tests used were unpaired t-test and Chi-square test. Results: The serum IL-1β levels were significantly (P 0.001) lesser in Group I in comparison to Group II. The salivary IL-1β levels remained insignificant between both the groups. However, in both the groups, the salivary IL-1β levels were significantly higher compared to the serum IL-1β levels. Conclusion: We found that the serum IL-1β level can be considered as a prospective biomarker for dysplasia, whereas salivary IL-1β alone needs more elaborated studies to account for its application as a potential biomarker in OPMD. [ABSTRACT FROM AUTHOR] |
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| Database: |
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