Bibliographic Details
| Title: |
Understanding the relationship between pachychoroid spectrum disorders and retinitis pigmentosa: A review of the evidence. |
| Authors: |
Chavan, Kasturi1, Chhablani, Jay2, Jalali, Subhadra3, Padhy, Srikanta Kumar1 srikanta.padhy@lvpei.org |
| Source: |
Indian Journal of Ophthalmology. Jul2024, Vol. 72 Issue 7, p956-961. 6p. |
| Subject Terms: |
*CHOROID, *RETINITIS pigmentosa, *RHODOPSIN, *DYSTROPHY, *POLYPOIDAL choroidal vasculopathy |
| Abstract: |
This study aims to investigate the relationship between pachychoroid spectrum disorders and retinitis pigmentosa (RP) or rod‑cone dystrophy through a comprehensive literature review. The purpose is to explore the association between these disorders, understand their underlying mechanisms, and summarize the existing hypotheses and opinions. A thorough review of the literature was conducted using PubMed, focusing on articles related to central serous chorioretinopathy (CSC), RP, pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, polypoidal choroidal vasculopathy, focal choroidal excavation, peripapillary pachychoroid neovasculopathy, and peripheral exudative hemorrhagic chorioretinopathy. Relevant studies were selected for a detailed narrative review and analysis. Several studies have reported the coexistence of CSC and RP, indicating a potential association between the two conditions. The dysfunction of the retinal pigment epithelium is proposed as a common factor. Choroidal thinning is observed in RP, but conflicting results exist regarding choroidal thickness (CT). While some studies support choroidal thinning in RP, others suggest preserved or increased thickness. Additionally, cases of pachychoroid neovasculopathy and polypoidal choroidal vasculopathy in RP have been reported, suggesting an overlap between these conditions. The literature suggests conflicting reports on CT changes in RP. Future research should focus on large‑scale studies using comprehensive imaging techniques, genetic analysis, and long‑term follow‑up to uncover the underlying mechanisms and determine the prevalence of pachychoroid spectrum disorders in RP patients. [ABSTRACT FROM AUTHOR] |
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| Database: |
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