| Title: |
Exploring the cognitive assessment potential of MRI‐based volumetric hippocampal segmentation in Parkinson's disease. |
| Authors: |
Tarhan, Merve1 (AUTHOR), Atalay, Başak1 (AUTHOR), Buz Yaşar, Ayşenur2 (AUTHOR) aysenurbuz@gmail.com, Özdilek, Fatma Betül3 (AUTHOR) |
| Source: |
Brain & Behavior. Jul2024, Vol. 14 Issue 7, p1-13. 13p. |
| Subject Terms: |
*HIPPOCAMPUS diseases, *MAGNETIC resonance imaging, *HIPPOCAMPUS (Brain), *PARKINSON'S disease, *COGNITIVE analysis |
| Abstract: |
Purpose: To investigate the potential of magnetic resonance imaging (MRI)‐based total and segmental hippocampus volume analysis in the assessment of cognitive status in Parkinson's disease (PD). Methods: We divided participants into three groups Group A‐Parkinson patients (Pp) with normal cognitive status (n = 25), Group B‐Pp with dementia (n = 17), and Group C‐healthy controls (n = 37). Three‐dimensional T1W Fast Spoiled Gradient Recalled Echo images were used for Volbrain hippocampus subfield segmentation. We used the "Winterburn" protocol, which divides the hippocampus into five segments, Cornu Ammonis (CA),CA2/CA3, CA4/dentate gyrus, stratum radiatum, lacunosum, and moleculare, and subiculum. Results: A total of 79 participants were included in the study, consisting of 42 individuals with PD (64.2% male) and 37 healthy controls (54.1% male). The mean age of PD was 60.9 ± 10.7 years and the mean age of control group was 59.27 ± 12.3 years. Significant differences were found in total hippocampal volumes between Group A and B (p =.047. Statistically significant group differences were found in total, right, and left CA1 volumes (analysis of variance [ANOVA]: F(2,76) = 8.098, p =.001; F(2,76) = 7.628, p =.001; F(2,76) = 5.084, p =.008, respectively), as well as in total subiculum volumes (ANOVA: F(2,76) = 4.368, p =.016). Post hoc tests showed that total subiculum volume was significantly lower in individuals with normal cognitive status (0.474 ± 0.116 cm3) compared to healthy controls (0.578 ± 0.151 cm3, p =.013). Conclusion: Volumetric hippocampal MRI can be used to assess the cognitive status of Pp. Longitudinal studies that evaluate Pp who progress from normal cognition to dementia are required to establish a causal relationship. [ABSTRACT FROM AUTHOR] |
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