Bibliographic Details
| Title: |
Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report. |
| Authors: |
Reddy, Balaswamy1, Nocera, Alessandra2,3,4, de Filippis, Renato5 defilippisrenato@gmail.com, Das, Soumitra6 |
| Source: |
Neuropsychiatric Investigation. Jun2024, Vol. 62 Issue 2, p73-75. 3p. |
| Subject Terms: |
*SYMPTOMS, *BILIRUBIN, *SYNDROMES, *RISPERIDONE, PSYCHIATRIC research |
| Abstract: |
Modern research in psychiatry is increasingly focusing on the possible identification of potentially useful biomarkers for early and differential diagnosis and patient-tailored therapy. In this context, old and new biomarkers are gaining attention, and bilirubin could represent a low-cost and widespread tool in this regard. In the following paper, we present a case report of a patient with juvenile-onset schizophrenia successfully treated with oral risperidone on 2 separate occasions, whose clinical exacerbation phases overlapped with hyperbilirubinemia peaks, while comfort phases were associated with serum bilirubin within the normal range. The patient was later diagnosed with Gilbert's syndrome, a benign, congenital condition of hyperbilirubinemia, with alternating phases of mostly asymptomatic bilirubin levels. This case highlights a possible relationship between psychotic symptoms and plasma bilirubin levels. While not representing by itself a sufficient condition to determine a relationship between the 2 phenomena, it poses a relevant question for future clinical and research investigations. [ABSTRACT FROM AUTHOR] |
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| Database: |
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