| Title: |
GLP and G9a histone methyltransferases as potential therapeutic targets for lymphoid neoplasms. |
| Authors: |
Silva-Carvalho, Amandda Évelin1 (AUTHOR), Filiú-Braga, Luma Dayane Carvalho1 (AUTHOR), Bogéa, Gabriela Muller Reche1 (AUTHOR), de Assis, Alan Jhones Barbosa2 (AUTHOR), Pittella-Silva, Fábio2 (AUTHOR), Saldanha-Araujo, Felipe1 (AUTHOR) felipearaujo@unb.br |
| Source: |
Cancer Cell International. 7/12/2024, Vol. 24 Issue 1, p1-14. 14p. |
| Subject Terms: |
*HISTONE methyltransferases, *DRUG target, *HEMATOLOGIC malignancies, *METHYLTRANSFERASES, *SMALL molecules, *TUMORS |
| Abstract: |
Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering the chromatin structure. Aberrant activation of HMTs has been widely reported in certain types of neoplastic cells. Among them, G9a/EHMT2 and GLP/EHMT1 are crucial for H3K9 methylation, and their dysregulation has been associated with tumor initiation and progression in different types of cancer. More recently, it has been shown that G9a and GLP appear to play a critical role in several lymphoid hematologic malignancies. Importantly, the key roles played by both enzymes in various diseases made them attractive targets for drug development. In fact, in recent years, several groups have tried to develop small molecule inhibitors targeting their epigenetic activities as potential anticancer therapeutic tools. In this review, we discuss the physiological role of GLP and G9a, their oncogenic functions in hematologic malignancies of the lymphoid lineage, and the therapeutic potential of epigenetic drugs targeting G9a/GLP for cancer treatment. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancer Cell International is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
