Bibliographic Details
| Title: |
The metal cofactor: stationary or mobile? |
| Authors: |
Hagedoorn, Peter-Leon1 (AUTHOR), Pabst, Martin1 (AUTHOR), Hanefeld, Ulf1 (AUTHOR) u.hanefeld@tudelft.nl |
| Source: |
Applied Microbiology & Biotechnology. 6/24/2024, Vol. 108 Issue 1, p1-15. 15p. |
| Subject Terms: |
*COFACTORS (Biochemistry), *METALS, *ALDOLASES, *BIOCHEMICAL substrates, *ISOMERASES, *METAL ions |
| Abstract: |
Metal cofactors are essential for catalysis and enable countless conversions in nature. Interestingly, the metal cofactor is not always static but mobile with movements of more than 4 Å. These movements of the metal can have different functions. In the case of the xylose isomerase and medium-chain dehydrogenases, it clearly serves a catalytic purpose. The metal cofactor moves during substrate activation and even during the catalytic turnover. On the other hand, in class II aldolases, the enzymes display resting states and active states depending on the movement of the catalytic metal cofactor. This movement is caused by substrate docking, causing the metal cofactor to take the position essential for catalysis. As these metal movements are found in structurally and mechanistically unrelated enzymes, it has to be expected that this metal movement is more common than currently perceived. Key points: • Metal ions are essential cofactors that can move during catalysis. • In class II aldolases, the metal cofactors can reside in a resting state and an active state. • In MDR, the movement of the metal cofactor is essential for substrate docking. [ABSTRACT FROM AUTHOR] |
|
Copyright of Applied Microbiology & Biotechnology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
