Bibliographic Details
| Title: |
Harmonised Methods for Detection of Insulin Immunogenicity. |
| Authors: |
Sathiya, Varadarajan1, Kumar, V. Ramesh2 rameshkumar.biotech@sathyabama.ac.in |
| Source: |
International Journal of Pharmaceutical Investigation. Apr-Jun2024, Vol. 14 Issue 2, p306-316. 11p. |
| Subject Terms: |
*IMMUNE response, *INSULIN, *INSULIN antibodies, *ANTIBODY formation, *INSULIN therapy, *PEOPLE with diabetes, *INSULIN receptors |
| Abstract: |
Studying the immunogenicity of insulin is crucial for managing and treating diabetes and other medical conditions. Although insulin therapy is proven effective for diabetic patients, the presence of insulin antibodies can diminish its effectiveness and lead to adverse immune reactions. Understanding the processes and factors affecting insulin immunogenicity is important to improve treatment outcomes and minimize complications. Research indicates that insulin's immunogenicity is influenced by various structural characteristics such as size, charge, and hydrophobicity. Additionally, factors like insulin dosage, frequency of administration, patient age, gender, genetic background, and mode of insulin delivery contribute to the likelihood of antibody formation. Therefore, optimizing insulin therapy for diabetic patients requires a comprehensive knowledge of insulin immunogenicity and effective insulin antibody detection assays. The development of advanced point-of-care immunoassays has enabled efficient screening for anti-insulin antibodies and assessment of insulin immunogenicity. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Pharmaceutical Investigation is the property of PHCOG.NET and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
